Patients with stupor or coma from fulminant hepatic failure were found to have high
cerebrospinal fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic …

Clinical criteria for the diagnosis of idiopathic Parkinson's disease, and akinetic-rigid
syndromes accompanying cerebral arteriosclerosis and senile dementia, are discussed. The …

Rats were given L‐tryptophan, 50 mg/kg ip, and its concentration in the CNS was monitored
in individual freely moving animals using repeated sampling of cisternal CSF and concurrent …

Three weeks after porto‐caval anastomosis, tryptophan and 5‐hydroxyindolylacetic acid
concentrations were‐greatly increased in rat brain regions. 5‐Hydroxytryptamine showed …

Psychiatric patients undergoing the psychosurgical operation of stereotactic subcaudate
tractotomy were infused intravenously with either saline or L‐tryptophan (15 mg/kg/h) …

Clinical, EEG, and biochemical features of 20 patients with narcolepsy and one patient with
the Kleine-Levin syndrome are described. The narcoleptic syndrome is a fairly common and …

Patients with chronic renal disease had low plasma total tryptophan but an abnormally high
proportion of this was in the free state. The subjects with encephalopathy had raised plasma …

Abstract Seventeen male Sprague-Dawley rats were trained to eight to nine correct
responses on a delayed spatial alternation test performed on alternate days in a T-maze …

Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-
hydroxytryptaminę) were determined in ventricular CSF of psychiatric patients undergoing …

METHODS Nine patients were studied. They all had been resident in a long-stay hospital for
between three months and seven years. They were selected from a population of 24 patients …