Background and objectives The last version of the EFNS dementia guidelines is from 2007.
In 2010, the revised guidelines for Alzheimer's disease (AD) were published. The current …

Introduction 3. Familial Alzheimer's disease 3.1. Amyloid precursor protein 3.2. Presenilin
genes 3.2. 1. Presenilin 1 gene 3.2. 2. Presenilin 2 gene 4. Sporadic Alzheimer's disease …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …

WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness, affecting 0.9–4% of women and 0.3% of men,–, with twin-based heritability …

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐E
uropean frontotemporal lobar degeneration (FTLD) cohort (n= 1,205), ascertained by the E …