Extrahepatic complement biosynthesis: where, when and why?
BP Morgan, P Gasque - Clinical and experimental immunology, 1997 - ncbi.nlm.nih.gov
The complement (C) system is a key component of innate immunity, playing a central role in
defence against microorganisms and in the processing of immune complexes. It is also a …
defence against microorganisms and in the processing of immune complexes. It is also a …
Complement components of the innate immune system in health and disease in the CNS
P Gasque, YD Dean, EP McGreal, J VanBeek… - …, 2000 - Elsevier
The innate immune system and notably the complement (C) system play important roles in
host defense to recognise and kill deleterious invaders or toxic entities, but activation at …
host defense to recognise and kill deleterious invaders or toxic entities, but activation at …
[HTML][HTML] Complement, a target for therapy in inflammatory and degenerative diseases
BP Morgan, CL Harris - Nature reviews Drug discovery, 2015 - nature.com
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
[HTML][HTML] C3 glomerulopathy: consensus report
MC Pickering, VD D'agati, CM Nester, RJ Smith… - Kidney international, 2013 - Elsevier
C3 glomerulopathy is a recently introduced pathological entity whose original definition was
glomerular pathology characterized by C3 accumulation with absent or scanty …
glomerular pathology characterized by C3 accumulation with absent or scanty …
Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts
MS Cragg, SM Morgan, HTC Chan… - Blood, The Journal …, 2003 - ashpublications.org
Despite the clinical success of anti-CD20 monoclonal antibody (mAb) in the treatment of
lymphoma, there remains considerable uncertainty about its mechanism of action. Here we …
lymphoma, there remains considerable uncertainty about its mechanism of action. Here we …
[HTML][HTML] Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies …
THJ Goodship, HT Cook, F Fakhouri, FC Fervenza… - Kidney international, 2017 - Elsevier
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure
FI Malik, JJ Hartman, KA Elias, BP Morgan… - Science, 2011 - science.org
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs
increase cardiac contractility indirectly through signaling cascades but are limited by their …
increase cardiac contractility indirectly through signaling cascades but are limited by their …
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.
S Meri, BP Morgan, A Davies, RH Daniels… - …, 1990 - ncbi.nlm.nih.gov
Human cells are relatively resistant to lysis by the homologous complement system. Here we
describe the mechanism of action of a recently discovered and widely distributed 18,000 …
describe the mechanism of action of a recently discovered and widely distributed 18,000 …
Immunopathology of secondary‐progressive multiple sclerosis
JW Prineas, EE Kwon, ES Cho… - Annals of Neurology …, 2001 - Wiley Online Library
Twenty‐three plaques obtained at early autopsy from 2 patients with secondary‐progressive
multiple sclerosis were examined immunohistochemically for microglia/macrophages, and …
multiple sclerosis were examined immunohistochemically for microglia/macrophages, and …
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome
EG de Jorge, CL Harris… - Proceedings of the …, 2007 - National Acad Sciences
Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children.
Mutations in one or more genes encoding complement-regulatory proteins have been …
Mutations in one or more genes encoding complement-regulatory proteins have been …