Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

The blood-brain barrier, while fundamental in maintaining homeostasis in the central
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …

Objective To characterize the association between commonly used anti-epileptic drugs
(AEDs) and plasma lipid levels in patients with epilepsy. Methods We sought observational …

The instruction of a competent living Teacher is doubtless the most efficient means of
acquiring any Language. Supplied with such help the Student requires little more than the …

The blood-brain barrier (BBB) is an important factor limiting the effectiveness of central
nervous system (CNS) therapeutics. MR-guided focused ultrasound (MRgFUS) is a …

Background Liquid biopsy is promising for early detection, monitoring of response, and
recurrence of cancer. The blood-brain barrier (BBB) limits the shedding of biomarker, such …

Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common,
often refractory, neuropsychiatric conditions for which new treatment approaches are …

The blood–brain barrier (BBB) protects the brain but is also an important obstacle for the
effective delivery of therapeutics in Alzheimer's disease and other neurodegenerative …

Background GBA1 mutation is the most common genetic risk factor for Parkinson's disease
(PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows …

Alcohol use disorder (AUD) is a highly prevalent, often refractory, medical illness. The
symptoms of AUD are driven by dysfunction in several neurocircuits centered on the nucleus …