New insights into the therapeutic potential of Girk channels
G protein-dependent signaling pathways control the activity of excitable cells of the nervous
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …
[HTML][HTML] Liquid biopsy in non-small cell lung cancer
…, C Teixido, B Garcia-Pelaez, C Aguado… - Frontiers in …, 2016 - frontiersin.org
Liquid biopsy analyses are already incorporated in the routine clinical practice in many
hospitals and oncology departments worldwide, improving the selection of treatments and …
hospitals and oncology departments worldwide, improving the selection of treatments and …
Intracellular protein degradation in mammalian cells: recent developments
In higher organisms, dietary proteins are broken down into amino acids within the digestive
tract but outside the cells, which incorporate the resulting amino acids into their metabolism …
tract but outside the cells, which incorporate the resulting amino acids into their metabolism …
[HTML][HTML] Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state
We have analyzed the folding state of cytosolic proteins imported in vitro into lysosomes,
using an approach originally developed by Eilers and Schatz,(Eilers, M., and Schatz …
using an approach originally developed by Eilers and Schatz,(Eilers, M., and Schatz …
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations
…, B Pérez, LR Desviat, C Aguado… - Proceedings of the …, 2004 - National Acad Sciences
Phenylketonuria patients harboring a subset of phenylalanine hydroxylase (PAH) mutations
have recently shown normalization of blood phenylalanine levels upon oral administration of …
have recently shown normalization of blood phenylalanine levels upon oral administration of …
Laforin, the most common protein mutated in Lafora disease, regulates autophagy
Lafora disease (LD) is an autosomal recessive, progressive myoclonus epilepsy, which is
characterized by the accumulation of polyglucosan inclusion bodies, called Lafora bodies, in …
characterized by the accumulation of polyglucosan inclusion bodies, called Lafora bodies, in …
Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy
O Criado, C Aguado, J Gayarre… - Human molecular …, 2012 - academic.oup.com
Lafora disease (LD), a fatal neurodegenerative disorder characterized by the presence of
intracellular inclusions called Lafora bodies (LBs), is caused by loss-of-function mutations in …
intracellular inclusions called Lafora bodies (LBs), is caused by loss-of-function mutations in …
Regulation of glycogen synthesis by the laforin–malin complex is modulated by the AMP-activated protein kinase pathway
…, M Sanchez-Piris, C Aguado… - Human molecular …, 2008 - academic.oup.com
Lafora progressive myoclonus epilepsy (LD) is a fatal autosomal recessive
neurodegenerative disorder characterized by the presence of glycogen-like intracellular …
neurodegenerative disorder characterized by the presence of glycogen-like intracellular …
Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations
…, B Pérez, LR Desviat, MA Martínez, C Aguado… - Human …, 2004 - Wiley Online Library
A subtype of phenylalanine hydroxylase (PAH) deficiency that responds to cofactor
(tetrahydrobiopterin, BH4) supplementation has been associated with phenylketonuria …
(tetrahydrobiopterin, BH4) supplementation has been associated with phenylketonuria …
L-DOPA oppositely regulates synaptic strength and spine morphology in D1 and D2 striatal projection neurons in dyskinesia
Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …