Stable clones of neural stem cells (NSCs) have been isolated from the human fetal
telencephalon. These self-renewing clones give rise to all fundamental neural lineages in …

Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare clinical entity, characterized
by a chronic inflammation causing thickening of the dura. Adequate therapeutic …

Background Previous trials have shown that pridopidine might reduce motor impairment in
patients with Huntington's disease. The aim of this study was to ascertain whether higher …

Based on the pathophysiological role of adenosine A2A receptors in HD, we have evaluated
the association of the 1976C/T single-nucleotide polymorphism in the ADORA2A gene …

Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has
been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental …

The aim of the present work was to investigate the preparation of low molecular weight
heparin (LMWH) nanoparticles (NP) as potential oral heparin carriers. The NP were …

Background and Purpose TRPM4 is a calcium‐activated non‐selective cation channel
expressed in many tissues and implicated in several diseases, and has not yet been …

Background Subthalamic nucleus deep brain stimulation (STN-DBS) has demonstrated its
efficacy on motor complications in advanced Parkinson's disease (PD) but does not modify …

Cell therapy in diverse organs has bloomed for degenerative diseases over the past
decade, following a previous period of development in which haematopoietic stem cells …

Herein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium
channel overexpressed in breast and prostate cancer, and its use to test the effect of …