The epidemiology of tremor in Parkinson's disease is not well examined. The prevalence of
Parkinson's disease is about 100–300 per 100,000, and the majority (70–100%) of these …

Since their discovery in 1998, the hypocretins (orexins)—peptides that are produced by a
group of neurons situated in the posterolateral hypothalamus—have been shown to excite …

The classification of the central disorders of hypersomnolence has undergone multiple
iterations in an attempt to capture biologically meaningful disease entities in the absence of …

Background: Fatigue is highly prevalent and has a negative impact on quality of life and
performance in a variety of disorders. The 9-item Fatigue Severity Scale (FSS) is one of the …

Sleep–wake disturbances (SWD) are common after traumatic brain injury (TBI). In acute TBI,
we recently found decreased CSF levels of hypocretin-1, a wake-promoting …

Objective: To determine the role of CSF hypocretin-1 in narcolepsy with and without
cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several …

Background 6 months after traumatic brain injury (TBI), almost three out of four patients
suffer from sleep–wake disturbances (SWD) such as post-traumatic hypersomnia (increased …

Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic
brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the …

Purpose: Considering the epileptogenic effect of cavernoma‐surrounding hemosiderin,
assumptions are made that resection only of the cavernoma itself may not be sufficient as …

Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively
assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain …