Abstract Interpretation of clinical trials comparing different drug regimens for Parkinson's
disease (PD) is complicated by the different dose intensities used: higher doses of levodopa …

Background Despite medical therapies and surgical interventions for Parkinson's disease
(PD), patients develop progressive disability. Physiotherapy aims to maximise functional …

Objective To assess the effectiveness of physiotherapy compared with no intervention in
patients with Parkinson's disease. Design Systematic review and meta-analysis of …

Background There is debate about whether the initial treatment for patients with Parkinson's
disease should be levodopa or a dopamine agonist. Methods In this prospective …

Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

Idiopathic intracranial hypertension is common in obese women and can lead to significant
visual impairment. First described more than 100 years ago, the cause of the disorder …

Objective To observe intracranial pressure in women with idiopathic intracranial
hypertension who follow a low energy diet. Design Prospective cohort study. Setting …

Background Despite medical therapies and surgical interventions for Parkinson's disease
(PD), patients develop progressive disability. The role of physiotherapy is to maximise …