Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the
diencephalon. A critical component of normal motor function, it has become a key target for …

Senescence affects the ability to utilize information about the likelihood of rewards for
optimal decision-making. Using functional magnetic resonance imaging in humans, we …

Immune-mediated neurological sequelae following infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) are becoming increasingly evident, and can affect …

Cerebral small vessel disease is a common condition associated with lacunar stroke,
cognitive impairment and significant functional morbidity. White matter hyperintensities and …

Detecting treatment efficacy using cognitive change in trials of cerebral small vessel disease
(SVD) has been challenging, making the use of surrogate markers such as magnetic …

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rfNa2C03, MeOH, H20, room temperature.'Swern oxidation.-^ NaOMe, MeOH, room …

Background and Purpose—Cerebral small-vessel disease is a major cause of cognitive
impairment. Perivascular spaces (PvS) occur in small-vessel disease, but their relationship …

This technical report describes a dynamic causal model of the spread of coronavirus through
a population. The model is based upon ensemble or population dynamics that generate …

Background Cachexia affects the majority of patients with advanced cancer and is
associated with a reduction in treatment tolerance, response to therapy, and duration of …