Colonic inflammation in Parkinson's disease
D Devos, T Lebouvier, B Lardeux, M Biraud… - Neurobiology of …, 2013 - Elsevier
Lewy pathology affects the gastrointestinal tract in Parkinson's disease (PD) and data from
recent genetic studies suggest a link between PD and gut inflammation. We therefore …
recent genetic studies suggest a link between PD and gut inflammation. We therefore …
Ferroptosis and its potential role in the physiopathology of Parkinson's Disease
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …
characterised by motor impairments as well as non-motor symptoms. While dopamine …
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
The molecular architecture of the nuclear pore complex
…, LM Veenhoff, W Zhang, J Kipper, D Devos… - Nature, 2007 - nature.com
Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa
that selectively transport cargoes across the nuclear envelope. To determine the molecular …
that selectively transport cargoes across the nuclear envelope. To determine the molecular …
Targeting chelatable iron as a therapeutic modality in Parkinson's disease
Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …
chelation strategy aimed at reducing oxidative damage associated with regional iron …
[HTML][HTML] Trial of deferiprone in Parkinson's disease
Background Iron content is increased in the substantia nigra of persons with Parkinson's
disease and may contribute to the pathophysiology of the disorder. Early research suggests …
disease and may contribute to the pathophysiology of the disorder. Early research suggests …
Proteome organization in a genome-reduced bacterium
The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating
organisms. To study the basic principles of bacterial proteome organization, we used …
organisms. To study the basic principles of bacterial proteome organization, we used …
Prediction of human protein function from post-translational modifications and localization features
We have developed an entirely sequence-based method that identifies and integrates
relevant features that can be used to assign proteins of unknown function to functional …
relevant features that can be used to assign proteins of unknown function to functional …
Determining the architectures of macromolecular assemblies
…, LM Veenhoff, W Zhang, J Kipper, D Devos… - Nature, 2007 - nature.com
To understand the workings of a living cell, we need to know the architectures of its
macromolecular assemblies. Here we show how proteomic data can be used to determine …
macromolecular assemblies. Here we show how proteomic data can be used to determine …
Practical limits of function prediction
D Devos, A Valencia - Proteins: Structure, Function, and …, 2000 - Wiley Online Library
The widening gap between known protein sequences and their functions has led to the
practice of assigning a potential function to a protein on the basis of sequence similarity to …
practice of assigning a potential function to a protein on the basis of sequence similarity to …