The pathophysiology of the vasovagal response

DL Jardine, W Wieling, M Brignole, JWM Lenders… - Heart Rhythm, 2018 - Elsevier
In part I of this study, we found that the classical studies on vasovagal syncope, conducted in
fit young subjects, overstated vasodilatation as the dominant hypotensive mechanism. Since …

The history of diagnosing carotid sinus hypersensitivity: why are the current criteria too sensitive?

CTP Krediet, SW Parry, DL Jardine, DG Benditt… - Europace, 2011 - academic.oup.com
The carotid sinus syndrome and carotid sinus hypersensitivity (CSH) are closely related
disorders. The first is characterized by syncope triggered by manipulation of the carotid …

Cardiac output and vasodilation in the vasovagal response: an analysis of the classic papers

W Wieling, DL Jardine, FJ de Lange, M Brignole… - Heart rhythm, 2016 - Elsevier
The simple faint is secondary to hypotension and bradycardia resulting in transient loss of
consciousness. According to Ohm's law applied to the circulation, BP= SVR× CO …

A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial

M Than, S Aldous, SJ Lord, S Goodacre… - JAMA internal …, 2014 - jamanetwork.com
Importance Patients with chest pain represent a high health care burden, but it may be
possible to identify a patient group with a low short-term risk of adverse cardiac events who …

[HTML][HTML] Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: a pragmatic randomized controlled trial embedded within practice

MP Than, JW Pickering, SJ Aldous, L Cullen… - Annals of emergency …, 2016 - Elsevier
Study objective A 2-hour accelerated diagnostic pathway based on the Thrombolysis in
Myocardial Infarction score, ECG, and troponin measures (ADAPT-ADP) increased early …

Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model

DL Jardine, CJ Charles, RK Ashton… - The Journal of …, 2005 - Wiley Online Library
The time course of cardiac sympathetic nerve activity (CSNA) following acute myocardial
infarction (MI) is unknown. We therefore undertook serial direct recordings of CSNA, arterial …

Mechanisms of vasovagal syncope in the young: reduced systemic vascular resistance versus reduced cardiac output

JM Stewart, MS Medow, R Sutton… - Journal of the …, 2017 - Am Heart Assoc
Background Syncope is a sudden transient loss of consciousness and postural tone caused
by cerebral hypoperfusion. The most common form is vasovagal syncope (VVS) …

Neurohormonal response to head-up tilt and its role in vasovagal syncope

DL Jardine, IC Melton, IG Crozier, SI Bennett… - American Journal of …, 1997 - ajconline.org
FIGURE 1. The hemodynamic responses to 60 head-up tilt (mean blood pressure, heart rate,
and left atrial index) in the normal group (open bars, n Å 9) and the syncopal group (slashed …

Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope

DL Jardine, IC Melton, IG Crozier… - American Journal …, 2002 - journals.physiology.org
The importance of cardiac output (CO) to blood pressure level during vasovagal syncope is
unknown. We measured thermodilution CO, mean blood pressure (MBP), and leg muscle …

Autonomic control of vasovagal syncope

DL Jardine, H Ikram, CM Frampton… - American Journal …, 1998 - journals.physiology.org
In the pathophysiological study of vasovagal syncope, the nature of the interaction between
baroreceptor sensitivity (BS), sympathetic withdrawal, and parasympathetic activity has yet …