We have examined the choline acetyltransferase [CAT] activity in autopsy samples of frontal
and temporal lobe cortex from 47 patients (31 with Alzheimer's disease, 4 with dementia due …

Polymersomes are polymer-based vesicular shells that form upon hydration of amphiphilic
block copolymers. These high molecular weight amphiphiles impart physicochemical …

Cortical biopsies were taken from the frontal lobe of 25 patients with presenile dementia.
Choline acetyltransferase (ChAT) activity, and in some specimens the high affinity uptake of …

Fifty-six brains from middle-aged and elderly normal as well as demented subjects and
patients with provisional clinical diagnosis of other neurological and psychiatric diseases …

Markers of serotonin synapses in entire temporal lobe and frontal and temporal neocortex
were examined for changes in Alzheimer's disease by use of both neurosurgical and …

Multiple neurotransmitter deficits found in recent autopsy studies of patients with Alzheimer's
disease may militate against the success of" simple cholinergic replacement" as treatment …

Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy
samples from patients with presenile dementia. For those patients in whom Alzheimer's …

Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding
of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue …

Seven markers of ascending (corticopetal) dopaminergic, noradrenergic and serotonergic
neurones and choline acetyltransferase activity have been studied postmortem in frontal and …

Indices of presynaptic serotonergic nerve endings were assayed in neocortical biopsy
samples from patients with histologically verified Alzheimer's disease. The concentrations of …