VNS therapy was delivered to patients for the first time in 1988. After 25 years, insight in the
antiepileptic and antidepressant mechanism of action of VNS has grown steadily. The effects …

Minimally invasive resection of brain tumours aims at removing as much pathological tissue
as possible while preserving essential brain functions. Therefore, the precise spatial …

Purpose: This pilot study prospectively evaluated the efficacy of long‐term deep brain
stimulation (DBS) in medial temporal lobe (MTL) structures in patients with MTL epilepsy …

A fundamental question about human memory is which brain structures are involved, and
when, in transforming experiences into memories. This experiment sought to identify neural …

This review focuses on some of the known and hypothetical pathophysiological mechanisms
underlying the motor symptoms in Parkinson's disease (PD). Current views on these …

We have addressed whether aberrant ongoing hypermutation can be detected in the proto-
oncogenes PIM1, c-MYC, RhoH/TTF, PAX5, and the tumor-suppressor gene CD95 in …

Purpose This study investigates the performance of a cardiac-based seizure detection
algorithm (CBSDA) that automatically triggers VNS (NCT01325623). Methods Thirty-one …

Primary central nervous system lymphomas (PCNSLs) have recently received considerable
clinical attention due to their increasing incidence. To clarify the histogenetic origin of these …

From 1987 to 1992, invasive EEG studies using subdural strips, grids or depth electrodes
were performed in a total of 160 patients with medically intractable epilepsy, in whom scalp …

Purpose Fifteen percent to 25% of patients with refractory epilepsy require invasive video–
electroencephalography (EEG) monitoring (IVEM) to precisely delineate the ictal‐onset …