User profiles for "author:E Ledger"
Mark E. LedgerSenior Lecturer, University of Birmingham Verified email at bham.ac.uk Cited by 5841 |
[HTML][HTML] Polymyxin and lipopeptide antibiotics: membrane-targeting drugs of last resort
EVK Ledger, A Sabnis, AM Edwards - Microbiology, 2022 - microbiologyresearch.org
The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …
Neurological manifestations of influenza infection in children and adults: results of a National British Surveillance Study
A Goenka, BD Michael, E Ledger, IJ Hart… - Clinical Infectious …, 2014 - academic.oup.com
Background. The emergence of influenza A (H1N1) 2009 was met with increased reports of
associated neurological manifestations. We aimed to describe neurological manifestations …
associated neurological manifestations. We aimed to describe neurological manifestations …
[HTML][HTML] Human serum triggers antibiotic tolerance in Staphylococcus aureus
EVK Ledger, S Mesnage, AM Edwards - Nature Communications, 2022 - nature.com
Staphylococcus aureus frequently causes infections that are challenging to treat, leading to
high rates of persistent and relapsing infection. Here, to understand how the host …
high rates of persistent and relapsing infection. Here, to understand how the host …
Ecological networks–beyond food webs
TC Ings, JM Montoya, J Bascompte… - Journal of animal …, 2009 - Wiley Online Library
Summary 1 A fundamental goal of ecological network research is to understand how the
complexity observed in nature can persist and how this affects ecosystem functioning. This is …
complexity observed in nature can persist and how this affects ecosystem functioning. This is …
[HTML][HTML] Antibiotic interceptors: creating safe spaces for bacteria
A Sabnis, EVK Ledger, V Pader, AM Edwards - PLoS pathogens, 2018 - journals.plos.org
Antibiotics have underpinned numerous advances including surgery, organ transplantation,
and cancer chemotherapy. Therefore, the emergence of bacterial pathogens that are …
and cancer chemotherapy. Therefore, the emergence of bacterial pathogens that are …
[HTML][HTML] Elevated antiphospholipid antibody titers and adverse pregnancy outcomes: analysis of a population-based hospital dataset
J Nodler, SR Moolamalla, EM Ledger… - BMC Pregnancy and …, 2009 - Springer
Background The primary objective of this study was to determine if elevated
antiphospholipid antibody titers were correlated with the presence of preeclampsia …
antiphospholipid antibody titers were correlated with the presence of preeclampsia …
[HTML][HTML] Growth and neurodevelopment in low birth weight versus normal birth weight infants from birth to 24 months, born in an obstetric emergency hospital in Haiti …
…, D Van Brusselen, H Roggeveen, E Ledger… - BMC pediatrics, 2021 - Springer
Background Low birthweight (LBW) infants are at higher risk of mortality and morbidity
(growth, chronic disease and neurological problems) during their life. Due to the high …
(growth, chronic disease and neurological problems) during their life. Due to the high …
[HTML][HTML] A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal
…, S Nightingale, NK Bhatta, R Singh, E Ledger… - PloS one, 2015 - journals.plos.org
Background Japanese encephalitis (JE) virus (JEV) is a mosquito-borne flavivirus found
across Asia that is closely related to West Nile virus. There is no known antiviral treatment for …
across Asia that is closely related to West Nile virus. There is no known antiviral treatment for …
Growth arrest of Staphylococcus aureus induces daptomycin tolerance via cell wall remodelling
EVK Ledger, AM Edwards - Mbio, 2023 - Am Soc Microbiol
Almost all bactericidal drugs require bacterial replication and/or metabolic activity for their
killing activity. When these processes are inhibited by bacteriostatic antibiotics, bacterial …
killing activity. When these processes are inhibited by bacteriostatic antibiotics, bacterial …
Brain perfusion in autism varies with age
J Wilcox, MT Tsuang, E Ledger, J Algeo… - Neuropsychobiology, 2002 - karger.com
Oursubjects consisted of 14 autistic individuals and 14 controls ranging in age from 3 to 37
years. A 99mTc HMPAO single photon emission computed tomogram (SPECT) was used to …
years. A 99mTc HMPAO single photon emission computed tomogram (SPECT) was used to …