An understanding of the neurobiological correlates of vulnerability to psychosis is
fundamental to research on schizophrenia. We systematically reviewed data from studies …

Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI)
tractography frequently require manual WM bundle segmentation, often called “virtual …

Background: Diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery
(FLAIR) MRI have high sensitivity and specificity for Creutzfeldt-Jakob disease (CJD). No …

Pelizaeus-Merzbacher disease (PMD) is a rare leukodystrophy caused by mutation of the
proteolipid protein 1 gene. Defective oligodendrocytes in PMD fail to myelinate axons …

Objective Rates of worsening and evolution to secondary progressive multiple sclerosis
(MS) may be substantially lower in actively treated patients compared to natural history …

Objective In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more
strongly than white matter (WM) atrophy with disability. The corresponding relationships in …

White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However …

In primary progressive aphasia (PPA), speech and language difficulties are caused by
neurodegeneration of specific brain networks. In the nonfluent/agrammatic variant (nfvPPA) …

Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS).
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …