Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

GG Kovacs, I Ferrer, LT Grinberg, I Alafuzoff… - Acta …, 2016 - Springer
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a
frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its …

Mixed brain pathologies in dementia: the BrainNet Europe consortium experience

GG Kovacs, I Alafuzoff, S Al-Sarraj… - Dementia and geriatric …, 2008 - karger.com
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease
forms are increasingly recognized. Methods: We performed a survey within brain banks of …

Which ante mortem clinical features predict progressive supranuclear palsy pathology?

G Respondek, C Kurz, T Arzberger… - Movement …, 2017 - Wiley Online Library
Background Progressive supranuclear palsy (PSP) is a neuropathologically defined disease
presenting with a broad spectrum of clinical phenotypes. Objective To identify clinical …

Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria

GU Höglinger, G Respondek, M Stamelou… - Movement …, 2017 - Wiley Online Library
Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria,
published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for …

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

MT Heneka, MP Kummer, A Stutz, A Delekate… - Nature, 2013 - nature.com
Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β
peptide drives cerebral neuroinflammation by activating microglia,. Indeed, amyloid-β …

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

C Venegas, S Kumar, BS Franklin, T Dierkes… - Nature, 2017 - nature.com
The spreading of pathology within and between brain areas is a hallmark of
neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β …

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

A Iranzo, E Tolosa, E Gelpi, JL Molinuevo… - The Lancet …, 2013 - thelancet.com
Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour
disorder (IRBD) represents the prodromal phase of a Lewy body disorder and that, with …

Conversion from subtypes of mild cognitive impairment to Alzheimer dementia

P Fischer, S Jungwirth, S Zehetmayer, S Weissgram… - Neurology, 2007 - AAN Enterprises
Objective: To compare the rates of conversion to Alzheimer dementia (AD) between
subtypes of mild cognitive impairment (MCI) in a community-based birth cohort investigated …

[HTML][HTML] Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients

A Iranzo, A Fernández-Arcos, E Tolosa, M Serradell… - PloS one, 2014 - journals.plos.org
Objective To estimate the risk for developing a defined neurodegenerative syndrome in a
large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up …

A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats

J van der Zee, I Gijselinck, L Dillen… - Human …, 2013 - Wiley Online Library
We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐E
uropean frontotemporal lobar degeneration (FTLD) cohort (n= 1,205), ascertained by the E …