The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of
accuracy in cases with full expression of classical clinical features. However, diagnostic …

Motor complications in Parkinson's disease (PD) result from the short half-life and irregular
plasma fluctuations of oral levodopa. When strategies of providing more continuous …

Background Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is a parasomnia
characterised by dream-enacting behaviours related to unpleasant dreams and loss of …

In advanced Parkinson's disease (PD) patients, continuous intra-duodenal infusion of
levodopa/carbidopa intestinal gel (LCIG) is an established approach in the management of …

Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour
disorder (IRBD) represents the prodromal phase of a Lewy body disorder and that, with …

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …

Objective To estimate the risk for developing a defined neurodegenerative syndrome in a
large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up …

Background Patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD)
may develop neurodegenerative conditions associated with substantia nigra dysfunction …

Lewy body (LB) diseases are characterized by alpha‐synuclein (AS) aggregates in the
central nervous system (CNS). Involvement of the peripheral autonomic nervous system …

Background Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease
(PD) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction …