Blood-brain barrier (BBB) breakdown, due to the concomitant disruption of the tight junctions
(TJs), normally required for the maintenance of BBB function, and to the altered transport of …

Huntington's disease is characterized by a complex and heterogeneous pathogenic profile.
Studies have shown that disturbance in lipid homeostasis may represent a critical …

Neurodegeneration of the striatum in Huntington disease (HD) is characterized by loss of
medium‐spiny neurons, huntingtin nuclear inclusions, reactive gliosis, and iron …

White matter abnormalities have been shown in presymptomatic and symptomatic
Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion …

Purpose To test in a longitudinal follow-up study whether basal glucose metabolism in
subjects with a genetic risk of Huntington disease (HD) may influence the onset of manifest …

White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and
symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study …

Objectives We investigated changes in gray matter (GM) and white matter (WM) in the whole
brain, including both cortical and subcortical structures, and their relationship with tremor …

Abstract Background Huntington Disease (HD) is a neurodegenerative disorder resulting
from the expansion of polyglutamine stretch in the huntingtin protein (Htt). Mutant HTT (mHtt) …

Objective To evaluate the role of iron deposition in subcortical nuclei of patients with
essential tremor (ET). Methods Twenty-three patients with ET underwent a standardized 3T …

Background Progressive supranuclear palsy (PSP) is a rare rapidly progressive,
neurodegenerative disease characterized by falls and ocular movement disturbances. The …