User profiles for "author:Fusako Usuki"

Fusako Usuki

Joint Research Center for Human Retrovirus Infection, Kagoshima University
Verified email at kufm.kagoshima-u.ac.jp
Cited by 1842

[HTML][HTML] Cellular conditions responsible for methylmercury-mediated neurotoxicity

M Fujimura, F Usuki - International Journal of Molecular Sciences, 2022 - mdpi.com
Methylmercury (MeHg) is a widely known environmental pollutant that causes severe
neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including …

[HTML][HTML] Methylmercury-mediated oxidative stress and activation of the cellular protective system

M Fujimura, F Usuki - Antioxidants, 2020 - mdpi.com
Methylmercury (MeHg) is a well-known neurotoxicant that causes severe intoxication in
humans. In Japan, it is referred to as Minamata disease, which involves two characteristic …

Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral …

M Fujimura, F Usuki, M Sawada, A Takashima - Neurotoxicology, 2009 - Elsevier
Methylmercury (MeHg) is a well-known neurotoxicant inducing neuronal degeneration in the
central nervous system. This in vivo study investigated the involvement of tau …

Inhibition of nonsense‐mediated mRNA decay rescues the phenotype in Ullrich's disease

F Usuki, A Yamashita, I Higuchi… - Annals of Neurology …, 2004 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) is an mRNA surveillance system that eliminates
aberrant mRNAs containing premature translation termination codons (PTCs). We evaluated …

[HTML][HTML] Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts

F Usuki, A Yamashita, I Kashima, I Higuchi, M Osame… - Molecular Therapy, 2006 - cell.com
Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
degrades aberrant mRNAs containing premature translation termination codons (PTCs). The …

[HTML][HTML] Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure

F Usuki, A Yamashita, M Fujimura - Journal of biological chemistry, 2011 - ASBMB
Methylmercury (MeHg) toxicity is a continuous environmental problem to human health. The
critical role of oxidative stress in the pathogenesis of MeHg cytotoxicity has been clarified …

In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat

F Usuki, A Yasutake, F Umehara, H Tokunaga… - Neuroscience …, 2001 - Elsevier
Methylmercury (MeHg) is a well-known neurotoxicant. MeHg-intoxication causes a
disturbance in mitochondrial energy metabolism in skeletal muscle and apoptosis in …

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

M Fujimura, F Usuki, M Kawamura, S Izumo - Toxicology and applied …, 2011 - Elsevier
Methylmercury (MeHg) is an environmental neurotoxicant which induces neuropathological
changes in both the central nervous and peripheral sensory nervous systems. Our recent …

[HTML][HTML] Methylmercury causes blood-brain barrier damage in rats via upregulation of vascular endothelial growth factor expression

T Takahashi, M Fujimura, M Koyama, M Kanazawa… - PLoS …, 2017 - journals.plos.org
Clinical manifestations of methylmercury (MeHg) intoxication include cerebellar ataxia,
concentric constriction of visual fields, and sensory and auditory disturbances. The …

Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat

M Nakamura, N Hachiya, K Murata, I Nakanishi… - Environment …, 2014 - Elsevier
Methylmercury (MeHg) is a major environmental neurotoxicant that causes damage to the
central nervous system. In Japan, industrial emission of MeHg has resulted in MeHg …