Fatigue is one of the most common and most disabling symptoms of multiple sclerosis (MS).
Although numerous studies have tried to reveal it, no definite pathogenesis factor behind …

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

The exact pathogenesis of multiple sclerosis (MS) is incompletely understood. Although auto-
immune responses have an important role in the development of hallmark focal …

Background Autonomic nervous system dysfunction is common after acute stroke and is
associated with elevated risk of cardiac arrhythmia and mortality. Heart rate variability and …

Male patients with fragile X syndrome lack FMR1 protein due to silencing of the FMR1 gene
by amplification of a CGG repeat and subsequent methylation of the promoter region. The …

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the
diagnostic workup of several neurological brain diseases. Reluctance to perform the …

Metachromatic leukodystrophy is a lysosomal sphingolipid storage disorder caused by the
deficiency of arylsulfatase A. The disease is characterized by progressive demyelination …

Transgenic fragile X knockout mice have been constructed to provide an animal model to
study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the …

Fmr1 knockout mice constitute a putative model of fragile X syndrome, the most common
form of heritable mental disability in humans. We have compared the performance of …

Background and purpose Cognitive impairment (CI) is found in about half of the multiple
sclerosis (MS) population and is an important contributor to employment status and social …