Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling
…, JD Rohrer, Genetic FTD Initiative (GENFI) - Neurology, 2021 - AAN Enterprises
Background and Objective Mutations in the MAPT gene cause frontotemporal dementia
(FTD). Most previous studies investigating the neuroanatomical signature of MAPT …
(FTD). Most previous studies investigating the neuroanatomical signature of MAPT …
Ventricular volume expansion in presymptomatic genetic frontotemporal dementia
Objective To characterize the time course of ventricular volume expansion in genetic
frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion …
frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion …
Longitudinal cognitive changes in genetic frontotemporal dementia within the GENFI cohort
…, JD Rohrer, Genetic FTD Initiative (GENFI) - Neurology, 2022 - AAN Enterprises
Background and Objectives Disease-modifying therapeutic trials for genetic frontotemporal
dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The …
dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The …
Analysis of person recognition deficits in genetic frontotemporal dementia
…, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2023 - Wiley Online Library
Background Semantic and socioemotional knowledge, including person recognition, can be
altered in frontotemporal dementia (FTD), and is often associated with the right temporal …
altered in frontotemporal dementia (FTD), and is often associated with the right temporal …
[HTML][HTML] Cognitive composites for genetic frontotemporal dementia: GENFI-Cog
Background Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia
(FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but …
(FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but …
[HTML][HTML] Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales
Background In patients with frontotemporal dementia, it has been shown that brain atrophy
occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating …
occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating …
Subtype and stage inference identifies distinct atrophy patterns in genetic frontotemporal dementia that MAP onto specific MAPT mutations: Imaging and non‐AD …
…, JD Rohrer, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2020 - Wiley Online Library
Background Mutations in the MAPT gene are known to cause frontotemporal dementia
(FTD), but there is heterogeneity in FTD phenotype across individuals. Here we used an …
(FTD), but there is heterogeneity in FTD phenotype across individuals. Here we used an …
A longitudinal analysis of the frontotemporal dementia rating scale as a sensitive measure of disease trajectory
…, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2023 - Wiley Online Library
Background Previous research in genetic frontotemporal dementia (FTD) has suggested that
the FTD Rating Scale (FRS) may be a more sensitive measure of disease severity than the …
the FTD Rating Scale (FRS) may be a more sensitive measure of disease severity than the …
Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study
A Pérez-Millan, S Borrego-Écija, JC van Swieten… - Journal of …, 2023 - Springer
Background and objectives The C9orf72 expansion is the most common genetic cause of
frontotemporal dementia (FTD) and/or motor neuron disease (MND). Corticospinal …
frontotemporal dementia (FTD) and/or motor neuron disease (MND). Corticospinal …
Impairment of episodic memory in genetic frontotemporal dementia: a GENFI study
…, Genetic FTD Initiative, GENFI… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction We aimed to assess episodic memory in genetic frontotemporal dementia (FTD)
with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was …
with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was …