Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling

…, JD Rohrer, Genetic FTD Initiative (GENFI) - Neurology, 2021 - AAN Enterprises
Background and Objective Mutations in the MAPT gene cause frontotemporal dementia
(FTD). Most previous studies investigating the neuroanatomical signature of MAPT …

Ventricular volume expansion in presymptomatic genetic frontotemporal dementia

…, JD Rohrer, EC Finger, Genetic FTD Initiative, GENFI - Neurology, 2019 - AAN Enterprises
Objective To characterize the time course of ventricular volume expansion in genetic
frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion …

Longitudinal cognitive changes in genetic frontotemporal dementia within the GENFI cohort

…, JD Rohrer, Genetic FTD Initiative (GENFI) - Neurology, 2022 - AAN Enterprises
Background and Objectives Disease-modifying therapeutic trials for genetic frontotemporal
dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The …

Analysis of person recognition deficits in genetic frontotemporal dementia

…, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2023 - Wiley Online Library
Background Semantic and socioemotional knowledge, including person recognition, can be
altered in frontotemporal dementia (FTD), and is often associated with the right temporal …

[HTML][HTML] Cognitive composites for genetic frontotemporal dementia: GENFI-Cog

JM Poos, KM Moore, J Nicholas, LL Russell… - Alzheimer's research & …, 2022 - Springer
Background Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia
(FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but …

[HTML][HTML] Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales

GG Fumagalli, P Basilico, A Arighi, M Bocchetta… - Alzheimer's research & …, 2018 - Springer
Background In patients with frontotemporal dementia, it has been shown that brain atrophy
occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating …

Subtype and stage inference identifies distinct atrophy patterns in genetic frontotemporal dementia that MAP onto specific MAPT mutations: Imaging and non‐AD …

…, JD Rohrer, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2020 - Wiley Online Library
Background Mutations in the MAPT gene are known to cause frontotemporal dementia
(FTD), but there is heterogeneity in FTD phenotype across individuals. Here we used an …

A longitudinal analysis of the frontotemporal dementia rating scale as a sensitive measure of disease trajectory

…, Genetic FTD Initiative (GENFI) - Alzheimer's & …, 2023 - Wiley Online Library
Background Previous research in genetic frontotemporal dementia (FTD) has suggested that
the FTD Rating Scale (FRS) may be a more sensitive measure of disease severity than the …

Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study

A Pérez-Millan, S Borrego-Écija, JC van Swieten… - Journal of …, 2023 - Springer
Background and objectives The C9orf72 expansion is the most common genetic cause of
frontotemporal dementia (FTD) and/or motor neuron disease (MND). Corticospinal …

Impairment of episodic memory in genetic frontotemporal dementia: a GENFI study

…, Genetic FTD Initiative, GENFI… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction We aimed to assess episodic memory in genetic frontotemporal dementia (FTD)
with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was …