Iron deficiency, with or without anemia, is extremely frequent worldwide, representing a
major public health problem. Iron replacement therapy dates back to the seventeenth …

Anemia in cancer patients is quite common, with remarkable negative impacts on quality of
life and overall prognosis. The pathogenesis is complex and typically multifactorial, with iron …

Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living
organisms. During infections, a battle for iron takes place between the human host and the …

Anemia affects a substantial fraction of the elderly population, representing a public health
problem that is predicted to further increase in coming years because of the demographic …

Aceruloplasminemia (ACP) is a rare, adult-onset, autosomal recessive disorder,
characterized by systemic iron overload due to mutations in the Ceruloplasmin gene (CP) …

Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the
key features of systemic sclerosis (SSc). ET-1 receptors (and) are expressed on endothelial …

Peripheral blood smear is a simple laboratory tool, which remains of invaluable help for
diagnosing primary and secondary abnormalities of blood cells despite advances in …

Older people are at risk for cobalamin (vitamin B 12) deficiency because of a number of
common disorders (eg, autoimmune gastritis) and drugs (eg, antacids) that may alter its …

Aceruloplasminemia is a rare autosomal recessive genetic disease characterized by mild
microcytic anemia, diabetes, retinopathy, liver disease, and progressive neurological …

Hereditary Hemochromatosis (HH) is a genetically heterogeneous disorder caused by
mutations in at least five different genes (HFE, HJV, TFR2, SLC40A1, HAMP) involved in the …