Alzheimer's disease is one of the most common causes of mental deterioration in elderly
people, accounting for around 50%-60% of the overall cases of dementia among persons …

Findings from longitudinal and cross-sectional studies suggest an association between high
blood pressure and dementia, and in turn the use of antihypertensives has been suggested …

Background The objective was to evaluate the efficacy and tolerability of donepezil (5 and
10 mg/day) compared with placebo in alleviating manifestations of mild to moderate …

Background The apolipoprotein E ε4 (APOE-ε4) allele is a risk factor for Alzheimer's disease
(AD), but it is neither essential nor sufficient for development of the disease. Other factors …

Objective: To evaluate the efficacy and safety of galantamine in the treatment of Alzheimer9s
disease. Design: Randomised, double blind, parallel group, placebo controlled trial. Setting …

Background There are many reports of psychological morbidity in spousal carers of patients
with dementia. The consequences of this increased stress on the immune system are …

Background Leuco-methylthioninium bis (hydromethanesulfonate; LMTM), a stable reduced
form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation …

Background The amyloid-β peptide Aβ 42 has been implicated in the pathogenesis of
Alzheimer's disease (AD). We aimed to test the effects of tarenflurbil, a selective Aβ 42 …

A viral aetiology has long been suspected for Alzheimer's disease (AD) but until now,
techniques have not been sufficiently sensitive to provide clear evidence for or against the …

Multiple neurotransmitter deficits found in recent autopsy studies of patients with Alzheimer's
disease may militate against the success of" simple cholinergic replacement" as treatment …