During the past decade the view of Parkinson's disease (PD) as a motor disorder has
changed significantly and currently it is recognized as a multisystem process with diverse …

Spinocerebellar ataxia type 3 or Machado‐Joseph disease is the most common
spinocerebellar ataxia worldwide, and the high frequency of nonmotor manifestations in …

Objectives: Using a family study design, we describe the motor and nonmotor phenotype in
probands with LRRK2 G2019S mutations and family members and compare these …

Objectives Intronic FGF14 GAA repeat expansions have recently been found to be a
common cause of hereditary ataxia (GAA-FGF14 ataxia; SCA27B). The global epidemiology …

Background REM sleep behaviour disorder (RBD) is typically linked to synucleinopathies
(SP). In this study we analyzed the utility and performance of RBD as a tool for the …

BACKGROUND: A mean of 10 years elapse before patients with Parkinson's disease (PD)
reach Hoehn & Yahr (H&Y) stage 4, and 14 years for stage 5. A small proportion of PD …

Objective To determine whether four key neuropsychiatric and sleep related features
associated with Parkinson's disease (PD) are associated with the motor handicap and …

The frequency of parkin mutations was evaluated in 30 families of highly diverse geographic
origin with early-onset autosomal recessive parkinsonism. Twelve different mutations, six of …

LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐
body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent …

The main clinical manifestations of the spinocerebellar ataxias (SCAs) result from the
involvement of the cerebellum and its connections. Cerebellar activity has been consistently …