The hippocampus in multiple sclerosis

MA Rocca, F Barkhof, J De Luca, J Frisén… - The Lancet …, 2018 - thelancet.com
Some of the clinical manifestations of multiple sclerosis, such as memory impairment and
depression, are, at least partly, related to involvement of the hippocampus. Pathological …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

[HTML][HTML] Gray matter imaging in multiple sclerosis: what have we learned?

HE Hulst, JJG Geurts - BMC neurology, 2011 - Springer
At the early onset of the 20 th century, several studies already reported that the gray matter
was implicated in the histopathology of multiple sclerosis (MS). However, as white matter …

Brain atrophy and lesion load predict long term disability in multiple sclerosis

V Popescu, F Agosta, HE Hulst, IC Sluimer… - Journal of Neurology …, 2013 - jnnp.bmj.com
Objective To determine whether brain atrophy and lesion volumes predict subsequent 10
year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic …

Regional DTI differences in multiple sclerosis patients

SD Roosendaal, JJG Geurts, H Vrenken, HE Hulst… - Neuroimage, 2009 - Elsevier
Diffusion tensor imaging (DTI) measures have shown to be sensitive to white matter (WM)
damage in multiple sclerosis (MS), not only inside focal lesions but also in user-defined …

Resting state networks change in clinically isolated syndrome

SD Roosendaal, MM Schoonheim, HE Hulst… - Brain, 2010 - academic.oup.com
Task-functional magnetic resonance imaging studies have shown that early cortical
recruitment exists in multiple sclerosis, which can partly explain the discrepancy between …

Cognitive impairment in MS: impact of white matter integrity, gray matter volume, and lesions

HE Hulst, MD Steenwijk, A Versteeg, PJW Pouwels… - Neurology, 2013 - AAN Enterprises
Objective: To investigate whether extent and severity of white matter (WM) damage, as
measured with diffusion tensor imaging (DTI), can distinguish cognitively preserved (CP) …

Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis

MM Schoonheim, HE Hulst, RB Brandt, M Strik… - Neurology, 2015 - AAN Enterprises
Objective: This study investigates whether changes in functional connectivity, diffusivity, and
volume of the thalamus can explain different severities of cognitive impairment in multiple …

Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study

AJC Eijlers, Q van Geest, I Dekker, MD Steenwijk… - Brain, 2018 - academic.oup.com
Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …

Total brain volume and corpus callosum size in medication-naive adolescents and young adults with autism spectrum disorder

CM Freitag, E Luders, HE Hulst, KL Narr… - Biological …, 2009 - Elsevier
BACKGROUND: Increased total brain volume (TBV) has been reported for children with
autism spectrum disorder (ASD) but studies in older ASD subjects have been contradictory …