Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death directly
related to epilepsy, and most frequently occurs in people with chronic epilepsy. The main …
related to epilepsy, and most frequently occurs in people with chronic epilepsy. The main …
Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?
PG Meregalli, AAM Wilde, HL Tan - Cardiovascular research, 2005 - academic.oup.com
After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized
worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits …
worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits …
Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www. brugadadrugs. org)
PG Postema, C Wolpert, AS Amin, V Probst… - Heart Rhythm, 2009 - Elsevier
BACKGROUND: Worldwide, the Brugada syndrome has been recognized as an important
cause of sudden cardiac death in individuals at a relatively young age. Importantly, many …
cause of sudden cardiac death in individuals at a relatively young age. Importantly, many …
[HTML][HTML] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
WS Simonet, DL Lacey, CR Dunstan, M Kelley… - cell, 1997 - cell.com
A novel secreted glycoprotein that regulates bone resorption has been identified. The
protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily …
protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily …
[HTML][HTML] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
DL Lacey, E Timms, HL Tan, MJ Kelley, CR Dunstan… - cell, 1998 - cell.com
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that
replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture …
replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture …
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
YY Kong, H Yoshida, I Sarosi, HL Tan, E Timms… - Nature, 1999 - nature.com
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
H Hsu, DL Lacey, CR Dunstan… - Proceedings of the …, 1999 - National Acad Sciences
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation
and activation has been identified via genomic analysis of a primary osteoclast precursor …
and activation has been identified via genomic analysis of a primary osteoclast precursor …
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
N Bucay, I Sarosi, CR Dunstan, S Morony… - Genes & …, 1998 - genesdev.cshlp.org
Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
J Li, I Sarosi, XQ Yan, S Morony… - Proceedings of the …, 2000 - National Acad Sciences
We have generated RANK (receptor activator of NF-κB) nullizygous mice to determine the
molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK …
molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK …
Long-term prognosis of patients diagnosed with Brugada syndrome: results from the FINGER Brugada Syndrome Registry
V Probst, C Veltmann, L Eckardt, PG Meregalli… - Circulation, 2010 - Am Heart Assoc
Background—Brugada syndrome is characterized by ST-segment elevation in the right
precordial leads and an increased risk of sudden cardiac death (SCD). Fundamental …
precordial leads and an increased risk of sudden cardiac death (SCD). Fundamental …