Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms

R Surges, RD Thijs, HL Tan, JW Sander - Nature Reviews Neurology, 2009 - nature.com
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death directly
related to epilepsy, and most frequently occurs in people with chronic epilepsy. The main …

Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?

PG Meregalli, AAM Wilde, HL Tan - Cardiovascular research, 2005 - academic.oup.com
After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized
worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits …

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www. brugadadrugs. org)

PG Postema, C Wolpert, AS Amin, V Probst… - Heart Rhythm, 2009 - Elsevier
BACKGROUND: Worldwide, the Brugada syndrome has been recognized as an important
cause of sudden cardiac death in individuals at a relatively young age. Importantly, many …

[HTML][HTML] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

WS Simonet, DL Lacey, CR Dunstan, M Kelley… - cell, 1997 - cell.com
A novel secreted glycoprotein that regulates bone resorption has been identified. The
protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily …

[HTML][HTML] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

DL Lacey, E Timms, HL Tan, MJ Kelley, CR Dunstan… - cell, 1998 - cell.com
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that
replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture …

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

YY Kong, H Yoshida, I Sarosi, HL Tan, E Timms… - Nature, 1999 - nature.com
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

H Hsu, DL Lacey, CR Dunstan… - Proceedings of the …, 1999 - National Acad Sciences
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation
and activation has been identified via genomic analysis of a primary osteoclast precursor …

Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

N Bucay, I Sarosi, CR Dunstan, S Morony… - Genes & …, 1998 - genesdev.cshlp.org
Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

J Li, I Sarosi, XQ Yan, S Morony… - Proceedings of the …, 2000 - National Acad Sciences
We have generated RANK (receptor activator of NF-κB) nullizygous mice to determine the
molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK …

Long-term prognosis of patients diagnosed with Brugada syndrome: results from the FINGER Brugada Syndrome Registry

V Probst, C Veltmann, L Eckardt, PG Meregalli… - Circulation, 2010 - Am Heart Assoc
Background—Brugada syndrome is characterized by ST-segment elevation in the right
precordial leads and an increased risk of sudden cardiac death (SCD). Fundamental …