Background Idiopathic inflammatory myopathies are chronic diseases with significant
mortality and morbidity. Whilst immunosuppressive and immunomodulatory therapies are …

Guillain Barré syndrome is one of the best examples of a post infectious immune disease
and offers insights into the mechanism of tissue damage in other more common autoimmune …

Objective. To develop a standardized nomenclature system for the neuropsychiatric
syndromes of systemic lupus erythematosus (NPSLE). Methods. An international …

Guillain-Barré syndrome (GBS) was first described in 1916 (Guillain G, 1916) and is
approaching its 100th anniversary. Our knowledge of the syndrome has hugely expanded …

The incidence of antecedent events and serological evidence of preceding infection were
studied in 100 patients with acute idiopathic neuropathy and age and sex matched control …

A prospective study in South-East England during 15 months in 1983-1984 recruited 100
patients with acute idiopathic neuropathy. After 12 months 67% had recovered completely …

Classically, the course of Charcot–Marie–Tooth (CMT) disease is gradually progressive. We
describe eight atypical patients who developed acute or subacute deterioration. Seven of …

An alternative pathway of Trp metabolism involves the conversion of Trp to kynurenine by
indoleamine-2, 3-dioxygenase, which leads to synthesis of the neurotoxin, quinolinic acid …

Objective Titin gene (TTN) mutations have been described in eight families with hereditary
myopathy with early respiratory failure (HMERF). Some of the original patients had features …

The postmortem findings are reported from 9 cases of the Guillain-Barré syndrome with
survival between 10 days and 1 yr. In 8 cases there was multifocal loss of myelin throughout …