Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a
number of neurological conditions compared with healthy controls (HC) and is a candidate …

Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis …

Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker
in MS, the most common demyelinating disease of the CNS. We have attempted to identify …

In most patients with multiple sclerosis, the disease initiates with a first attack or clinically
isolated syndrome. At this phase, magnetic resonance imaging is an important predictor of …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

Objective: To (1) determine the value of the recently proposed criteria of neuromyelitis optica
(NMO) spectrum disorder (NMOSD) that unify patients with NMO and those with limited …

The choice of appropriate control group (s) is critical in cerebrospinal fluid (CSF) biomarker
research in multiple sclerosis (MS). There is a lack of definitions and nomenclature of …

The prognostic role of cerebrospinal fluid molecular biomarkers determined in early
pathogenic stages of multiple sclerosis has yet to be defined. In the present study, we aimed …

Background: The authors have recently described that intrathecal IgM synthesis (ITMS)
correlates with a higher disability in patients with clinically definite MS (CDMS). Objective: To …

Objective: To determine the prognostic value of selected biomarkers in clinically isolated
syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. Methods …