Deep brain stimulation

JS Perlmutter, JW Mink - Annu. Rev. Neurosci., 2006 - annualreviews.org
Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …

The focal dystonias: current views and challenges for future research

HA Jinnah, A Berardelli, C Comella… - Movement …, 2013 - Wiley Online Library
The most common forms of dystonia are those that develop in adults and affect a relatively
isolated region of the body. Although these adult‐onset focal dystonias are most prevalent …

Research priorities in spasmodic dysphonia

CL Ludlow, CH Adler, GS Berke… - … —Head and Neck …, 2008 - journals.sagepub.com
Objective To identify research priorities to increase understanding of the pathogenesis,
diagnosis, and improved treatment of spasmodic dysphonia. Study Design and Setting A …

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez… - Nature …, 2014 - nature.com
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

CW Shults, D Oakes, K Kieburtz, MF Beal… - Archives of …, 2002 - jamanetwork.com
Background Parkinson disease (PD) is a degenerative neurological disorder for which no
treatment has been shown to slow the progression. Objective To determine whether a range …

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

A Beilina, IN Rudenko, A Kaganovich… - Proceedings of the …, 2014 - National Acad Sciences
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

[PDF][PDF] Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy

S Lesage, V Drouet, E Majounie, V Deramecourt… - The American Journal of …, 2016 - cell.com
Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Decreased [18F] spiperone binding in putamen in idiopathic focal dystonia

JS Perlmutter, MK Stambuk, J Markham… - Journal of …, 1997 - Soc Neuroscience
In this study we have investigated the pathophysiology of two idiopathic focal dystonias:
hand cramp with excessive cocontractions of agonist and antagonist hand or forearm …

A stereotactic method of anatomical localization for positron emission tomography

PT Fox, JS Perlmutter, ME Raichle - Journal of computer assisted …, 1985 - journals.lww.com
Surgicalxtant methods for anatomical localization within a physiological image are
inadequate for precise regional correlations between anatomy and physiology. We have …

Resting state functional connectivity of the striatum in Parkinson's disease

CD Hacker, JS Perlmutter, SR Criswell, BM Ances… - Brain, 2012 - academic.oup.com
Classical accounts of the pathophysiology of Parkinson's disease have emphasized
degeneration of dopaminergic nigrostriatal neurons with consequent dysfunction of cortico …