Fluctuations in performance in patients with Parkinson's disease on chronic levodopa
therapy (the" on-off" effect) are due to several factors. The increasing severity during …

The patient with Parkinson's disease on chronic levodopa therapy, like the diabetic on
insulin, is dependent on the drug. Like the diabetic, the patient with Parkinson's disease may …

The actions of melatonin on the sleep-wake cycle were investigated by means of a
randomised, double-blind, placebo-controlled trial in 8 subjects with a delayed sleep phase …

Publisher Summary This chapter discusses that Parkinson's disease, although in most
respects a chronic, progressive disorder, can also be seen as a paroxysmal condition …

Fourteen subjects are described in whom a clinical diagnosis of the delayed sleep phase
syndrome was made. The condition is multi-factorial, dependent on lifestyle, mood and …

Sleep paralysis is a common condition with a prevalence of 5-62%. Although most affected
people have single or infrequent episodes, sleep paralysis may be recurrent, or occur in …

In 10 parkinsonian patients with severe, chaotic clinical response fluctuations, oral levodopa
treatment was replaced by continuous intravenous infusion of levodopa (with orally …

There is a widespread distribution of dopamine receptors throughout the body (1). From the
viewpoint of the treatment of Parkinson's disease, these can be divided into three main …

The hypnotic action of melatonin 5 mg po was explored in 15 subjects with
psychophysiological insomnia in a double‐blind controlled self‐report questionnaire study …

The cause (s) of response fluctuations in patients with Parkinson's disease treated
chronically with levodopa is unknown. In some subjects it is difficult to establish a clear …