Background Neuropsychiatric symptoms are common features of Huntington's disease (HD).
Whereas most studies have focused on cognitive and neuroimaging markers of disease …

Background Up to 30% of patients with schizophrenia are resistant to antipsychotic drug
treatment, with 60% of such cases also failing to respond to clozapine. Deep brain …

Background Apathy is the neuropsychiatric syndrome that correlates most highly with
Huntington's disease progression, and, like early patterns of neurodegeneration, is …

Background The relationship between neuropsychiatric symptoms (NPS) and other clinical
dimensions in Huntington's disease (HD) is controversial. This longitudinal study analyzed …

A cognitive stimulating lifestyle has been observed to confer cognitive benefits in multiple
neurodegenerative diseases. However, the underlying neurobiological basis of this …

Background Progressive cognitive decline is an inevitable feature of Huntington's disease
(HD) but specific criteria and instruments are still insufficiently developed to reliably classify …

Huntington's disease (HD) is a genetic neurodegenerative disease which involves a triad of
motor, cognitive and psychiatric disturbances. However, there is great variability in the …

Background Apathy, a common neuropsychiatric disturbance in Huntington's disease (HD),
is subserved by a complex neurobiological network. However, no study has yet employed a …

Background Cognitive impairment is an essential feature of Huntington's disease (HD) and
dementia is a predictable outcome in all patients. However, validated instruments to assess …

Reference in language consists in using words to identify entities, which are then available
to be referenced again. Re-referencing establishes referential dependencies, which are a …