Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances
Discovery and development of clinically useful biomarkers for Alzheimer's disease (AD) and
related dementias have been the focus of recent research efforts. While cerebrospinal fluid …
related dementias have been the focus of recent research efforts. While cerebrospinal fluid …
[HTML][HTML] Plasma osteopontin as a biomarker of Alzheimer's disease and vascular cognitive impairment
Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer's
disease (AD) are frequently associated comorbidities in the elderly, sharing common risk …
disease (AD) are frequently associated comorbidities in the elderly, sharing common risk …
Plasma P‐tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant …
Introduction There is increasing evidence that phosphorylated tau (P‐tau181) is a specific
biomarker for Alzheimer's disease (AD) pathology, but its potential utility in non‐White …
biomarker for Alzheimer's disease (AD) pathology, but its potential utility in non‐White …
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration
Alzheimer's disease (AD) is characterized by accumulation of β‐amyloid plaques (AP) and
neurofibrillary tangles (NFT) in the cortex, together with synaptic loss and amyloid …
neurofibrillary tangles (NFT) in the cortex, together with synaptic loss and amyloid …
[HTML][HTML] Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer's disease but not Lewy body dementias
Background Chronically dysregulated neuroinflammation has been implicated in
neurodegenerative dementias, with separate studies reporting increased brain levels of …
neurodegenerative dementias, with separate studies reporting increased brain levels of …
Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients …
Introduction Plasma neurofilament light chain (NfL) is a potential biomarker for
neurodegeneration in Alzheimer's disease (AD), ischemic stroke, and non‐dementia cohorts …
neurodegeneration in Alzheimer's disease (AD), ischemic stroke, and non‐dementia cohorts …
[HTML][HTML] Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment
Background There has been ongoing research impetus to uncover novel blood-based
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …
Serum Placental Growth Factor as a Marker of Cerebrovascular Disease Burden in Alzheimer's Disease
Background: Concomitant cerebrovascular diseases (CeVD) have been identified as an
important determinant of Alzheimer's disease (AD) progression. Development of robust …
important determinant of Alzheimer's disease (AD) progression. Development of robust …
[HTML][HTML] Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer's disease and vascular dementia
Background Alzheimer's disease (AD) and vascular dementia (VaD) are two of the
commonest causes of dementia in the elderly. Of the myriad biomolecules implicated in …
commonest causes of dementia in the elderly. Of the myriad biomolecules implicated in …
[HTML][HTML] Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort
In the brain, the extracellular matrix (ECM) composition shapes the neuronal
microenvironment and can undergo substantial changes with cerebral pathology. Brevican …
microenvironment and can undergo substantial changes with cerebral pathology. Brevican …