The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

JJ Zarranz, J Alegre… - Annals of Neurology …, 2004 - Wiley Online Library
Familial parkinsonism and dementia with cortical and subcortical Lewy bodies is
uncommon, and no genetic defect has been reported in the previously described sibships …

Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease

JC Gómez-Esteban, B Tijero, J Somme, R Ciordia… - Journal of …, 2011 - Springer
The objective of this study is to assess how the non-motor symptoms of Parkinson's disease
(PD), such as depression, cognitive deterioration, neuropsychiatric and sleep disorders …

Restless legs syndrome in Parkinson's disease

JC Gómez‐Esteban, JJ Zarranz, B Tijero… - Movement …, 2007 - Wiley Online Library
The present study explores the frequency of RLS in PD and focuses on the clinical
differences between patients with and without restless legs syndrome (RLS). A cross …

Prevalence of neuropsychiatric symptoms in Alzheimer's disease and vascular dementia

M Fernández-Martínez, J Castro… - Current Alzheimer …, 2008 - ingentaconnect.com
Objetive: The study aimed to describe the prevalence and severity of neuropsychiatric
symptoms in patients with Alzheimer's disease (AD) and vascular dementia (VaD). Patients …

Nocturnal hypertension and dysautonomia in patients with Parkinson's disease: are they related?

K Berganzo, B Díez-Arrola, B Tijero, J Somme… - Journal of …, 2013 - Springer
Orthostatic hypotension and supine hypertension frequently coexist in Parkinson's disease
(PD) patients, leading to visceral damage and increased mortality rates. The aim of this …

Initial neuropsychological impairments in patients with the E46K mutation of the α-synuclein gene (PARK 1)

JH Somme, JC Gomez-Esteban, A Molano… - Journal of the …, 2011 - Elsevier
INTRODUCTION: In 2004 we described the mutation E46K of the α-Synuclein (SNCA).
These patients show Parkinson's disease with early cognitive impairment, sleep disorders …

Use of ziprasidone in parkinsonian patients with psychosis

JC Gómez-Esteban, JJ Zarranz, F Velasco… - Clinical …, 2005 - journals.lww.com
Twelve patients with Parkinson disease and psychosis were included in an open-label 12-
week trial of ziprasidone. Two patients withdrew from the treatment because of adverse …

Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain

MC González-Fernández, E Lezcano, OA Ross… - Parkinsonism & related …, 2007 - Elsevier
Herein we describe a comparative clinical and genetic study of Lrrk2-associated
parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and …

Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain

IF Mata, CM Hutter, MC González-Fernández… - Neurogenetics, 2009 - Springer
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene together represent the most
common genetic determinant of Parkinson's disease (PD) identified to date. The vast …

SCOPA-AUT scale in different parkinsonisms and its correlation with (123) I-MIBG cardiac scintigraphy

K Berganzo, B Tijero, JH Somme, V Llorens… - Parkinsonism & related …, 2012 - Elsevier
INTRODUCTION: Our objective was to assess the usefulness of the Scales for Outcomes in
Parkinson's disease–Autonomic (SCOPA-AUT) in the differential diagnosis of Parkinsonisms …