User profiles for "author:Justin Cross"
Justin R CrossMemorial Sloan Kettering Cancer Center Verified email at mskcc.org Cited by 27671 |
Connecting copper and cancer: from transition metal signalling to metalloplasia
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …
the cell. Recent progress in studying transition metal signalling has forged new links …
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Intestinal microbes provide multicellular hosts with nutrients and confer resistance to
infection. The delicate balance between pro-and anti-inflammatory mechanisms, essential …
infection. The delicate balance between pro-and anti-inflammatory mechanisms, essential …
[PDF][PDF] The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate
PS Ward, J Patel, DR Wise, O Abdel-Wahab… - Cancer cell, 2010 - cell.com
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas
can lead to the production of 2-hydroxyglutarate (2HG). Here, we report that tumor 2HG is …
can lead to the production of 2-hydroxyglutarate (2HG). Here, we report that tumor 2HG is …
ATP-citrate lyase links cellular metabolism to histone acetylation
KE Wellen, G Hatzivassiliou, UM Sachdeva, TV Bui… - Science, 2009 - science.org
Histone acetylation in single-cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA)
synthetase enzymes that use acetate to produce acetyl-CoA. Metazoans, however, use …
synthetase enzymes that use acetate to produce acetyl-CoA. Metazoans, however, use …
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
CG Buffie, V Bucci, RR Stein, PT McKenney, L Ling… - Nature, 2015 - nature.com
The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that
contribute to health, including colonization resistance against intestinal pathogens. Many …
contribute to health, including colonization resistance against intestinal pathogens. Many …
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
CM Krawczyk, T Holowka, J Sun… - Blood, The Journal …, 2010 - ashpublications.org
Dendritic cells (DCs) are key regulators of innate and acquired immunity. The maturation of
DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and …
DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and …
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
DR Wise, PS Ward, JES Shay… - Proceedings of the …, 2011 - National Acad Sciences
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and
cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions …
cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions …
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
The role of cellular metabolism in regulating cell proliferation and differentiation remains
poorly understood. For example, most mammalian cells cannot proliferate without …
poorly understood. For example, most mammalian cells cannot proliferate without …
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Brain metastasis represents a substantial source of morbidity and mortality in various
cancers, and is characterized by high resistance to chemotherapy. Here we define the role …
cancers, and is characterized by high resistance to chemotherapy. Here we define the role …
[HTML][HTML] Intestinal Blautia is associated with reduced death from graft-versus-host disease
The relationship between intestinal microbiota composition and acute graft-versus-host
disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well …
disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well …