User profiles for "author:Karl Herholz"

Karl Herholz

Professor
Verified email at manchester.ac.uk
Cited by 36087

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

H Hampel, R Frank, K Broich, SJ Teipel… - Nature reviews Drug …, 2010 - nature.com
Advances in therapeutic strategies for Alzheimer's disease that lead to even small delays in
onset and progression of the condition would significantly reduce the global burden of the …

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

GB Frisoni, M Boccardi, F Barkhof, K Blennow… - The Lancet …, 2017 - thelancet.com
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …

The nucleus accumbens: a target for deep brain stimulation in obsessive–compulsive-and anxiety-disorders

V Sturm, D Lenartz, A Koulousakis, H Treuer… - Journal of chemical …, 2003 - Elsevier
We considered clinical observations in patients with obsessive–compulsive-and anxiety-
disorders, who underwent bilateral anterior capsulotomy, as well as anatomical and …

Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET

K Herholz, E Salmon, D Perani, JC Baron, V Holthoff… - Neuroimage, 2002 - Elsevier
A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics
and an automated voxel-based procedure, is presented and validated in a large data set …

Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

L Mosconi, WH Tsui, K Herholz, A Pupi… - Journal of nuclear …, 2008 - Soc Nuclear Med
This multicenter study examined 18F-FDG PET measures in the differential diagnosis of
Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies …

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

G Chételat, J Arbizu, H Barthel, V Garibotto… - The Lancet …, 2020 - thelancet.com
Various biomarkers are available to support the diagnosis of neurodegenerative diseases in
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …

Progressive derangement of periinfarct viable tissue in ischemic stroke

WD Heiss, M Huber, GR Fink… - Journal of Cerebral …, 1992 - journals.sagepub.com
Sixteen patients were studied by multitracer positron emission tomography (PET) within 6–
48 (mean of 23) h of onset of a hemispheric ischemic stroke and again 13–25 (mean of 15.6) …

Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways

R Hilker, AV Thomas, JC Klein, S Weisenbach… - Neurology, 2005 - AAN Enterprises
Objective: To assess neurochemical deficits in patients with Parkinson disease (PD)
associated dementia (PDD) in vivo. Methods: The authors performed combined PET with N …

MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET

L Mosconi, D Perani, S Sorbi, K Herholz, B Nacmias… - Neurology, 2004 - AAN Enterprises
Objectives: To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET
measures with the APOE genotype would improve prediction of the conversion from mild …

Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease

D Anchisi, B Borroni, M Franceschi… - Archives of …, 2005 - jamanetwork.com
Background Subjects with amnesic mild cognitive impairment (aMCI) may include patients at
high risk for progression to Alzheimer disease (AD) and a population with different …