[HTML][HTML] Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional …
RI Scahill, P Zeun, K Osborne-Crowley… - The Lancet …, 2020 - thelancet.com
Background Disease-modifying treatments are in development for Huntington's disease;
crucial to their success is to identify a timepoint in a patient's life when there is a measurable …
crucial to their success is to identify a timepoint in a patient's life when there is a measurable …
[HTML][HTML] Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult …
EB Johnson, CS Parker, RI Scahill, S Gregory… - …, 2021 - thelancet.com
Abstract Background Pathological processes in Huntington's disease (HD) begin many
years prior to symptom onset. Recently we demonstrated that in a premanifest cohort …
years prior to symptom onset. Recently we demonstrated that in a premanifest cohort …
Neurofilament light-associated connectivity in young-adult Huntington's disease is related to neuronal genes
Upregulation of functional network connectivity in the presence of structural degeneration is
seen in the premanifest stages of Huntington's disease (preHD) 10–15 years from clinical …
seen in the premanifest stages of Huntington's disease (preHD) 10–15 years from clinical …
Validation of remote collection and quantification of blood Neurofilament light in neurological diseases.
Promising blood-based biomarkers of neuropathology have emerged with potential for
therapeutic development and disease monitoring. However, these tools will require …
therapeutic development and disease monitoring. However, these tools will require …
F59 Huntington's disease young adult study (HD-YAS)
P Zeun, J Lowe, K Osborne-Crowley, C O'Callaghan… - 2018 - jnnp.bmj.com
HD-YAS will study a cohort of young adult HD Gene Expansion Carriers (HDGEC) decades
before expected symptom onset to characterize the very earliest signs of disease-related …
before expected symptom onset to characterize the very earliest signs of disease-related …
D06 Influencing Huntington's disease monitoring and therapeutic development with remote quantification of blood neurofilament light protein
LM Byrne, JL Schultz, S Field, K Fayer, Y Hassan… - 2022 - jnnp.bmj.com
Background Neurofilament light protein (NfL) has emerged as the leading biomarker
candidate for disease progression and early detection of adult-onset Huntington's Disease …
candidate for disease progression and early detection of adult-onset Huntington's Disease …
F05 Biological and clinical characteristics of gene carriers far from predicted onset in the hd-yas study: a cross-sectional analysis
R Scahill, P Zeun, K Osborne-Crowley, E Johnson… - 2021 - jnnp.bmj.com
Background Disease-modifying treatments are in development for Huntington's disease
(HD); crucial to their success in delaying or preventing onset is to identify a timepoint when …
(HD); crucial to their success in delaying or preventing onset is to identify a timepoint when …
Longitudinal follow up of the Huntington's Disease Young Adult Study (HD-YAS 2.0)
F Mena, M Michael, F Kate, H Nichola, S Rachael… - 2023 - jnnp.bmj.com
Background Huntington's disease (HD) is an autosomal dominant neurodegenerative
condition. The Young Adult Study (HD-YAS) characterised the earliest pathological …
condition. The Young Adult Study (HD-YAS) characterised the earliest pathological …
Exploring the early neuropathology of Huntington's disease using 7T MRI and MEG in HD-YAS 2.0
M Michael, F Mena, N Mitsuko, F Kate, MC Peter… - 2023 - jnnp.bmj.com
Background The Huntington's Disease Young Adult Study (HD-YAS) provided a detailed
analysis of early premanifest Huntington's disease (preHD) participants along with age and …
analysis of early premanifest Huntington's disease (preHD) participants along with age and …
[CITATION][C] Detection of Early Neurodegeneration with Fluid Biomarkers in the HD Young Adult Study
P Zeun, RI Scahill… - …, 2020 - SPRINGER ONE NEW YORK …