Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies
C Smith, N Malek, K Grosset, B Cullen… - Journal of Neurology …, 2019 - jnnp.bmj.com
Background Dementia is a common, debilitating feature of late Parkinson's disease (PD). PD
dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer's …
dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer's …
Medicine‐taking behavior: Implications of suboptimal compliance in Parkinson's disease
KA Grosset, JL Reid, DG Grosset - Movement disorders: official …, 2005 - Wiley Online Library
Management of Parkinson's disease (PD) depends primarily on oral medication. There are
several drug classes and multiple doses and formulations, which make optimizing therapy …
several drug classes and multiple doses and formulations, which make optimizing therapy …
Suboptimal medication adherence in Parkinson's disease
KA Grosset, I Bone, DG Grosset - Movement disorders: official …, 2005 - Wiley Online Library
Patients take less medication than prescribed in many disease areas but evidence for
suboptimal therapy adherence in Parkinson's disease (PD) is limited. A single‐center …
suboptimal therapy adherence in Parkinson's disease (PD) is limited. A single‐center …
Genome‐wide association studies of cognitive and motor progression in Parkinson's disease
Background There are currently no treatments that stop or slow the progression of
Parkinson's disease (PD). Case–control genome‐wide association studies have identified …
Parkinson's disease (PD). Case–control genome‐wide association studies have identified …
Adherence to antiparkinson medication in a multicenter European study
D Grosset, A Antonini, M Canesi… - … : official journal of the …, 2009 - Wiley Online Library
Two small studies reported suboptimal therapy adherence in Parkinson's disease. We
conducted a larger multicenter European study to assess medicine‐taking behavior …
conducted a larger multicenter European study to assess medicine‐taking behavior …
Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease
N Malek, MA Lawton, DMA Swallow… - Movement …, 2016 - Wiley Online Library
Objective The purpose of this study was to examine the relationship between vascular
disease (and vascular risk factors), cognition and motor phenotype in Parkinson's disease …
disease (and vascular risk factors), cognition and motor phenotype in Parkinson's disease …
Developing and validating Parkinson's disease subtypes and their motor and cognitive progression
M Lawton, Y Ben-Shlomo, MT May, F Baig… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objectives To use a data-driven approach to determine the existence and natural history of
subtypes of Parkinson's disease (PD) using two large independent cohorts of patients newly …
subtypes of Parkinson's disease (PD) using two large independent cohorts of patients newly …
Striatal Dopamine Loss in Early Parkinson's Disease: Systematic Review and Novel Analysis of Dopamine Transporter Imaging
N Heng, N Malek, MA Lawton, A Nodehi… - Movement Disorders …, 2023 - Wiley Online Library
Background Neuropathological studies, based on small samples, suggest that symptoms of
Parkinson's disease (PD) emerge when dopamine/nigrostriatal loss is around 50–80 …
Parkinson's disease (PD) emerge when dopamine/nigrostriatal loss is around 50–80 …
Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study
N Malek, RS Weil, C Bresner, MA Lawton… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objectives To examine the influence of the glucocerebrosidase (GBA) mutation carrier state
on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at …
on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at …
Problematic gambling on dopamine agonists: not such a rarity
KA Grosset, G Macphee, G Pal… - … : official journal of the …, 2006 - Wiley Online Library
Excessive gambling is recognized with dopamine agonist therapy, but the prevalence is
unknown. We assessed the prevalence of excess gambling by specific prospective enquiry …
unknown. We assessed the prevalence of excess gambling by specific prospective enquiry …