BACKGROUND: Studies examining the way in which cognitive impairment is associated
with depression have produced inconsistent findings. Different severity of depressed mood …

Background Inflammatory markers are raised in cross-sectional studies of depressed
patients and may represent an important mediating factor for behaviour, neural plasticity and …

In this review of the last 5 years' developments in research into depression we focus on
recent advances and current controversies. We cover epidemiology and basic science as …

The identification of resting state networks (RSNs) and the quantification of their functional
connectivity in resting-state fMRI (rfMRI) are seriously hindered by the presence of artefacts …

Cumulative meta-analyses are used to evaluate the extent to which further studies are
needed to confirm or refute a hypothesis. We used this approach to assess observational …

Objectives To estimate 10 year decline in cognitive function from longitudinal data in a
middle aged cohort and to examine whether age cohorts can be compared with cross …

BackgroundThe aetiology of treatment-resistant major depression is little understood; its
apparent intractability may reflect brain abnormality. MethodMagnetic resonance images of …

Forty patients with a major depressive episode were divided into equal endogenous and
neurotic sub-groups using the Newcastle scale. They were all rated on the 17-item Hamilton …

Objectives To investigate whether moderate alcohol consumption has a favourable or
adverse association or no association with brain structure and function. Design …

BackgroundThe hypothesis that schizophrenia is neurodevelopmental was investigated in a
prospective study of young people with a postulated 10–15% risk for the development of …