Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review

LC Guedes, JJ Ferreira, MM Rosa, M Coelho… - Parkinsonism & related …, 2010 - Elsevier
BACKGROUND: The LRRK2 G2019S mutation is the most frequent known cause of familial
and sporadic Parkinson's disease. Knowledge of its worldwide frequency distribution is …

[HTML][HTML] Clinical trials in palliative care: a systematic review of their methodological characteristics and of the quality of their reporting

…, M Rosário, J Alarcăo, L Correia-Guedes… - BMC palliative …, 2017 - Springer
Background Over the past decades there has been a significant increase in the number of
published clinical trials in palliative care. However, empirical evidence suggests that there …

FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

AD Fonzo, MCJ Dekker, P Montagna, A Baruzzi… - Neurology, 2009 - AAN Enterprises
Background: The combination of early-onset, progressive parkinsonism with pyramidal tract
signs has been known as pallido-pyramidal or parkinsonian-pyramidal syndrome since the …

Are genetic and idiopathic forms of Parkinson's disease the same disease?

L Correia Guedes, T Mestre, TF Outeiro… - Journal of …, 2020 - Wiley Online Library
Genetic forms represent a small fraction of Parkinson's disease (PD) but their discovery has
revolutionized research in the field, putting α‐synuclein in the spotlight, and uncovering …

Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients

…, D Neutel, L Correia Guedes… - European Journal of …, 2015 - Wiley Online Library
Background Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a
conspicuous pathological feature of Parkinson's disease (PD) and is related to the loss of …

[HTML][HTML] Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease

H Vicente Miranda, R Cássio, L Correia-Guedes… - Scientific reports, 2017 - nature.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical
motor features associated. Pathologically, it is characterized by the intracellular …

Survival, mortality, causes and places of death in a European Huntington's disease prospective cohort

…, N Goncalves, L CorreiaGuedes… - Movement disorders …, 2017 - Wiley Online Library
Background Huntington's disease (HD) is a rare and fatal inherited genetic disorder
characterized by progressive motor, cognitive, and behavioral impairment. It leads to …

Dairy intake and Parkinson's disease: a Mendelian randomization study

…, M Toft, L Pihlstrřm, L Correia Guedes… - Movement …, 2022 - Wiley Online Library
Background Previous prospective studies highlighted dairy intake as a risk factor for
Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal …

[HTML][HTML] miR-335 targets LRRK2 and mitigates inflammation in Parkinson's disease

…, PA Dionísio, MM Gaspar, L Correia Guedes… - Frontiers in cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is mainly driven by dopaminergic neuronal degeneration in the
substantia nigra pars compacta accompanied by chronic neuroinflammation. Despite being …

Worldwide barriers to genetic testing for movement disorders

…, P Chana, A Darling, L Correia Guedes… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Despite enormous advances in identifying genetic variants
responsible for many neurological diseases, access to genetic testing may be limited in …