[HTML][HTML] O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway

CM Ferrer, TP Lynch, VL Sodi, JN Falcone, LP Schwab… - Molecular cell, 2014 - cell.com
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-
acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O …

[HTML][HTML] Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase …

F Fumagalli, V Calbi, MGN Sora, M Sessa, C Baldoli… - The Lancet, 2022 - thelancet.com
Background Effective treatment for metachromatic leukodystrophy (MLD) remains a
substantial unmet medical need. In this study we investigated the safety and efficacy of …

Dopamine and Huntington's disease

LC Schwab, SN Garas, J Drouin-Ouellet… - Expert review of …, 2015 - Taylor & Francis
Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative
disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre …

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

L Schwab, L Goroncy, S Palaniyandi, S Gautam… - Nature medicine, 2014 - nature.com
Acute graft-versus-host disease (GVHD) considerably limits wider usage of allogeneic
hematopoietic cell transplantation (allo-HCT). Antigen-presenting cells and T cells are …

[HTML][HTML] Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

LP Schwab, DL Peacock, D Majumdar, JF Ingels… - Breast Cancer …, 2012 - Springer
Introduction Overexpression of the oxygen-responsive transcription factor hypoxia-inducible
factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse …

The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways

A Slominski, TK Kim, AA Brożyna, Z Janjetovic… - Archives of biochemistry …, 2014 - Elsevier
To study the effect of melanogenesis on HIF-1α expression and attendant pathways, we
used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic …

[HTML][HTML] ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

DLP Brooks, LP Schwab, R Krutilina, DN Parke… - Molecular cancer, 2016 - Springer
Abstract Background Hypoxia-inducible factors (HIFs) are well-established mediators of
tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several …

Magnetic bénard convection

L Schwab, U Hildebrandt, K Stierstadt - Journal of Magnetism and Magnetic …, 1983 - Elsevier
An experiment was performed to examine the influence of a homogeneous vertical magnetic
field on the Bénard convection in a ferrofluid layer. The critical temperature difference was …

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

…, M Follo, T Wertheimer, L Schwab… - Blood, The Journal …, 2015 - ashpublications.org
Abstract Interleukin (IL)-33 binding to the receptor suppression of tumorigenicity 2 (ST2)
produces pro-inflammatory and anti-inflammatory effects. Increased levels of soluble ST2 …

mTOR/MYC axis regulates O-GlcNAc transferase expression and O-GlcNAcylation in breast cancer

VL Sodi, S Khaku, R Krutilina, LP Schwab… - Molecular Cancer …, 2015 - AACR
Cancers exhibit altered metabolism characterized by increased glucose and glutamine
uptake. The hexosamine biosynthetic pathway (HBP) uses glucose and glutamine, and …