Motivational processes underlie behaviors that enrich the human experience, and
impairments in motivation are commonly observed in psychiatric illness. While motivated …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …

Although compulsive sexual behaviour (CSB) has been conceptualized as a “behavioural”
addiction and common or overlapping neural circuits may govern the processing of natural …

Discrete yet overlapping frontal-striatal circuits mediate broadly dissociable cognitive and
behavioural processes. Using a recently developed multi-echo resting-state functional MRI …

The Internet provides a large source of novel and rewarding stimuli, particularly with respect
to sexually explicit materials. Novelty-seeking and cue-conditioning are fundamental …

Mounting evidence supports the rapid antidepressant efficacy of the N-methyl-d-aspartate
receptor antagonist, ketamine, for treating major depressive disorder (MDD); however, its …

Patients with major depressive disorder (MDD) exhibit higher levels of rumination, ie,
repetitive thinking patterns and exaggerated focus on negative states. Rumination is known …

Background Why do we jump the gun or speak out of turn? Waiting impulsivity has a
preclinical basis as a predictor for the development of addiction. Here, we mapped the …

Increased levels of peripheral cytokines have been previously associated with depression in
preclinical and clinical research. Although the precise nature of peripheral immune …