Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease with no effective
treatment. Drug development has been hampered by the lack of biomarkers that aid in early …

The migration of cells is a complex process that is dependent on the properties of the
surrounding environment. In vivo, the extracellular environment is complex with a wide …

Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous
pathological mechanisms resulting in a heterogeneous patient population. Using …

Objective Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with a complex
etiology that lacks biomarkers predicting disease progression. The objective of this study …

Cytoplasmic stress granules (SGs) are dynamic foci containing translationally arrested
mRNA and RNA-binding proteins (RBPs) that form in response to a variety of cellular …

A focused library of twenty-one cationic poly (amino ethers) was synthesized following ring-
opening polymerization of two diglycidyl ethers by different oligoamines. The polymers were …

Advances in the design and assembly of in vitro organotypic liver and gastrointestinal (GI)
models can accelerate our understanding of metabolism, nutrient absorption, and the effect …

Gene therapy has garnered significant attention as a therapeutic approach for bladder
cancer but efficient delivery and gene expression remain major hurdles. The goal of this …

Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells
(NPCs). However, systems biology studies of the liver have primarily focused on …

Background The hypothalamus is the ultimate modulator of appetite and energy balance
and therefore sensitive to changes in nutritional state. Chicks from lines selected for low …