Purpose: To determine the short-and long-term efficacy and toxicity of the high-dose
intravenous bolus interleukin 2 (IL-2) regimen in patients with metastatic melanoma. Patients …

Solvent-based delivery vehicles for chemotherapy agents have been instrumental in
providing a means for hydrophobic agents to be administered intravenously. These solvents …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer
of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular …

Introduction The strange behaviour of electrogenerated hydrogen disolved in palladium has
been studied for well over 100 years and lately these studies have been extended to …

Background The association between current use of oral contraceptives and increased risk
of venous thromboembolism (VTE) has been firmly established. Although data-sheets for …

Purpose ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter
particle, free of solvents, was compared with polyethylated castor oil–based standard …

We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped
this locus and tested it for association with stroke. We found the strongest association in the …

Abstract ABI-007, an albumin-bound, 130-nm particle form of paclitaxel, was developed to
avoid Cremophor/ethanol-associated toxicities in Cremophor-based paclitaxel (Taxol) and …

Abstract Background: Abraxane®(ABI-007) is a novel 130-nm, albumin-bound (nab™)
particle form of paclitaxel designed to utilize endogenous albumin pathways to increase …