Integrated care pathways

H Campbell, R Hotchkiss, N Bradshaw, M Porteous - Bmj, 1998 - bmj.com
Background Many initiatives have been introduced in the past two decades to improve
clinical effectiveness and thereby patient care. Foremost among these have been clinical …

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer

FVN Din, E Theodoratou, SM Farrington, A Tenesa… - Gut, 2010 - gut.bmj.com
Background Previous studies have shown that aspirin and other non-steroidal anti-
inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest …

Educating health-care professionals about genetics and genomics

AE Guttmacher, ME Porteous, JD McInerney - Nature Reviews Genetics, 2007 - nature.com
To biomedical researchers, this is the'genome era'. Advances in genetics and genomics
such as the sequence of the human genome, the human haplotype map, open access …

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

KA McAllister, KM Grogg, DW Johnson, CJ Gallione… - Nature …, 1994 - nature.com
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder
characterized by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for …

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

DW Johnson, JN Berg, MA Baldwin, CJ Gallione… - Nature …, 1996 - nature.com
Hereditary haemorrhagic telangiectasia, or Osler–Rendu–Weber (ORW) syndrome, is an
autosomal dominant vascular dysplasia. So far, two loci have been demonstrated for ORW …

International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia

ME Faughnan, VA Palda, G Garcia-Tsao… - Journal of medical …, 2011 - jmg.bmj.com
Background HHT is an autosomal dominant disease with an estimated prevalence of at least
1/5000 which can frequently be complicated by the presence of clinically significant …

Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

N Mavaddat, S Peock, D Frost, S Ellis… - JNCI: Journal of the …, 2013 - academic.oup.com
Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

BW Zanke, CMT Greenwood, J Rangrej, R Kustra… - Nature …, 2007 - nature.com
Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with …

[HTML][HTML] Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer

E Castro, C Goh, D Olmos, E Saunders… - Journal of Clinical …, 2013 - ncbi.nlm.nih.gov
Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant
Metastasis, and Poor Survival Outcomes in Prostate Cancer - PMC Back to Top Skip to main …

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

A Tenesa, SM Farrington, JGD Prendergast… - Nature …, 2008 - nature.com
In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …