Problematic Internet use (PIU), which has become a global social issue, can be broadly
conceptualized as an inability to control one's use of the Internet which leads to negative …

Background A growing body of research has analyzed the potential risks of problematic
Facebook use for mental health and well-being. The current meta-analysis is the first to …

Isolated complex I deficiency, the most frequent OXPHOS disorder in infants and children, is
genetically heterogeneous. Mutations have been found in seven mitochondrial DNA …

Background Metastatic melanoma is an untreatable cancer lacking reliable and non-
invasive markers of disease progression. Exosomes are small vesicles secreted by normal …

The classic phenotype of Fabry disease, X-linked α-galactosidase A (α-Gal A) deficiency,
has an estimated incidence of∼ 1 in 50,000 males. The recent recognition of later-onset …

Type I interferons (IFNs) are cytokines exhibiting antiviral and antitumor effects, including
multiple activities on immune cells. However, the importance of these cytokines in the early …

In the current study we sought to extend our understanding of vulnerability and protective
factors (the Big Five personality traits, health anxiety, and COVID-19 psychological distress) …

Background: Resistance to antitumor agents is a major cause of treatment failure in patients
with cancer. Some mechanisms of tumor resistance to cytotoxic drugs may involve increased …

The central aim of our study was to widen the mental health response to the COVID-19
pandemic by developing and evaluating a measure that could be used to identify the …

Proton pumps like the vacuolar-type H+ ATPase (V-ATPase) are involved in the control of
cellular pH in normal and tumor cells. Treatment with proton pump inhibitors (PPI) induces …