Multiple system atrophy: α‐synuclein and neuronal degeneration
M Yoshida - Neuropathology, 2007 - Wiley Online Library
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that encompasses
olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy–Drager …
olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy–Drager …
Phosphorylated and cleaved TDP‐43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP‐43 proteinopathy
T Arai, M Hasegawa, T Nonoka, F Kametani… - …, 2010 - Wiley Online Library
Transactivation response (TAR) DNA‐binding protein of Mr 43 kDa (TDP‐43) is a major
component of the tau‐negative and ubiquitin‐positive inclusions that characterize …
component of the tau‐negative and ubiquitin‐positive inclusions that characterize …
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
T Arai, M Hasegawa, H Akiyama, K Ikeda… - Biochemical and …, 2006 - Elsevier
Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are
common pathological features in frontotemporal lobar degeneration (FTLD) with or without …
common pathological features in frontotemporal lobar degeneration (FTLD) with or without …
[HTML][HTML] Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
A Tarutani, T Adachi, H Akatsu, Y Hashizume… - Acta …, 2022 - Springer
Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …
Structure-based classification of tauopathies
The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
There are numerous observations confirming that microglia expressing major
histocompatibility complex (MHC) class II molecules are associated with the central nervous …
histocompatibility complex (MHC) class II molecules are associated with the central nervous …
Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
M Hasegawa, T Arai, T Nonaka… - Annals of Neurology …, 2008 - Wiley Online Library
Objective TAR DNA‐binding protein of 43kDa (TDP‐43) is deposited as cytoplasmic and
intranuclear inclusions in brains of patients with frontotemporal lobar degeneration with …
intranuclear inclusions in brains of patients with frontotemporal lobar degeneration with …
The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy
K Mori, M Iijima, H Koike, N Hattori, F Tanaka… - Brain, 2005 - academic.oup.com
We assessed the clinicopathological features of 92 patients with primary Sjögren's
syndrome-associated neuropathy (76 women, 16 men, 54.7 years, age at onset). The …
syndrome-associated neuropathy (76 women, 16 men, 54.7 years, age at onset). The …
[PDF][PDF] Prion-like properties of pathological TDP-43 aggregates from diseased brains
T Nonaka, M Masuda-Suzukake, T Arai, Y Hasegawa… - Cell reports, 2013 - cell.com
TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients
with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS) …
with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS) …
Structures of α-synuclein filaments from multiple system atrophy
M Schweighauser, Y Shi, A Tarutani, F Kametani… - Nature, 2020 - nature.com
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …