Aquaporin water channels in the nervous system
MC Papadopoulos, AS Verkman - Nature Reviews Neuroscience, 2013 - nature.com
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …
[HTML][HTML] Aquaporin-4 and brain edema
MC Papadopoulos, AS Verkman - Pediatric nephrology, 2007 - Springer
Abstract Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain,
predominantly in astrocyte foot processes at the borders between the brain parenchyma and …
predominantly in astrocyte foot processes at the borders between the brain parenchyma and …
Aquaporin 4 and neuromyelitis optica
MC Papadopoulos, AS Verkman - The Lancet Neurology, 2012 - thelancet.com
Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
S Saadoun, MC Papadopoulos, M Hara-Chikuma… - Nature, 2005 - nature.com
Abstract Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …
Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema
ABSTRACT Aquaporin‐4 (AQP4) is the major water channel in the brain, expressed
predominantly in astroglial cell membranes. Initial studies in AQP4‐deficient mice showed …
predominantly in astroglial cell membranes. Initial studies in AQP4‐deficient mice showed …
Aquaporins: important but elusive drug targets
AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system
associated with autoantibodies against the glial water channel protein aquaporin-4. It has …
associated with autoantibodies against the glial water channel protein aquaporin-4. It has …
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation
S Saadoun, MC Papadopoulos… - Journal of cell …, 2005 - journals.biologists.com
Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous
system, facilitates water movement into and out of the brain. Here, we identify a novel role for …
system, facilitates water movement into and out of the brain. Here, we identify a novel role for …
Aquaporins—new players in cancer biology
AS Verkman, M Hara-Chikuma… - Journal of molecular …, 2008 - Springer
The aquaporins (AQPs) are small, integral-membrane proteins that selectively transport
water across cell plasma membranes. A subset of AQPs, the aquaglyceroporins, also …
water across cell plasma membranes. A subset of AQPs, the aquaglyceroporins, also …
Pathophysiology of septic encephalopathy: a review
MC Papadopoulos, DC Davies, RF Moss… - Critical care …, 2000 - journals.lww.com
Objectives Encephalopathy is a common complication of sepsis. This review describes the
different pathologic mechanisms that may be involved in its etiology. Data Sources The …
different pathologic mechanisms that may be involved in its etiology. Data Sources The …