Aquaporin water channels in the nervous system

MC Papadopoulos, AS Verkman - Nature Reviews Neuroscience, 2013 - nature.com
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

[HTML][HTML] Aquaporin-4 and brain edema

MC Papadopoulos, AS Verkman - Pediatric nephrology, 2007 - Springer
Abstract Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain,
predominantly in astrocyte foot processes at the borders between the brain parenchyma and …

Aquaporin 4 and neuromyelitis optica

MC Papadopoulos, AS Verkman - The Lancet Neurology, 2012 - thelancet.com
Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …

Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

S Saadoun, MC Papadopoulos, M Hara-Chikuma… - Nature, 2005 - nature.com
Abstract Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …

Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema

MC Papadopoulos, GT Manley, S Krishna… - The FASEB …, 2004 - Wiley Online Library
ABSTRACT Aquaporin‐4 (AQP4) is the major water channel in the brain, expressed
predominantly in astroglial cell membranes. Initial studies in AQP4‐deficient mice showed …

Aquaporins: important but elusive drug targets

AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

S Saadoun, P Waters, BA Bell, A Vincent, AS Verkman… - Brain, 2010 - academic.oup.com
Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system
associated with autoantibodies against the glial water channel protein aquaporin-4. It has …

Involvement of aquaporin-4 in astroglial cell migration and glial scar formation

S Saadoun, MC Papadopoulos… - Journal of cell …, 2005 - journals.biologists.com
Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous
system, facilitates water movement into and out of the brain. Here, we identify a novel role for …

Aquaporins—new players in cancer biology

AS Verkman, M Hara-Chikuma… - Journal of molecular …, 2008 - Springer
The aquaporins (AQPs) are small, integral-membrane proteins that selectively transport
water across cell plasma membranes. A subset of AQPs, the aquaglyceroporins, also …

Pathophysiology of septic encephalopathy: a review

MC Papadopoulos, DC Davies, RF Moss… - Critical care …, 2000 - journals.lww.com
Objectives Encephalopathy is a common complication of sepsis. This review describes the
different pathologic mechanisms that may be involved in its etiology. Data Sources The …