Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but
its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS …

Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …

The relationship between movement disorders and substance abuse, which we previously
reviewed, is updated. We examine these relationships bidirectionally with focus on drugs of …

Hyperkinetic states are common in human movement disorders, but their neural basis
remains uncertain. One such condition is dyskinesia, a serious adverse effect of medical and …

Dystonia is a movement disorder characterized by repetitive twisting muscle contractions
and postures,. Its molecular pathophysiology is poorly understood, in part owing to limited …

Objective: Estimates of the penetrance of LRRK2 G2019S vary widely (24%–100%),
reflective of differences in ascertainment, age, sex, ethnic group, and genetic and …

OBJECT The ClearPoint real-time interventional MRI-guided methodology for deep brain
stimulation (DBS) lead placement may offer advantages to frame-based approaches and …

Background Deep brain stimulation (DBS) of the subthalamic nucleus is an established
therapeutic option for managing motor symptoms of Parkinson's disease. We conducted a …

OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The
development of neuromodulation therapies depends on a better understanding of these …

In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by
therapeutic deep-brain stimulation (DBS) and this has been proposed as important to the …