[HTML][HTML] Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
[HTML][HTML] Dying cell clearance and its impact on the outcome of tumor radiotherapy
K Lauber, A Ernst, M Orth, M Herrmann… - Frontiers in oncology, 2012 - frontiersin.org
The induction of tumor cell death is one of the major goals of radiotherapy and has been
considered to be the central determinant of its therapeutic outcome for a long time. However …
considered to be the central determinant of its therapeutic outcome for a long time. However …
[HTML][HTML] Current concepts in clinical radiation oncology
M Orth, K Lauber, M Niyazi, AA Friedl, M Li… - Radiation and …, 2014 - Springer
Based on its potent capacity to induce tumor cell death and to abrogate clonogenic survival,
radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical …
radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical …
Emerging competency methods for the future
TR Athey, MS Orth - … : Published in Cooperation with the School …, 1999 - Wiley Online Library
Competency‐based applications have gained a foothold in HR practice worldwide;
however, changes in the business environment and the structure of work itself are …
however, changes in the business environment and the structure of work itself are …
[PDF][PDF] Identification of genetic factors that modify clinical onset of Huntington's disease
JM Lee, VC Wheeler, MJ Chao, JPG Vonsattel… - Cell, 2015 - cell.com
As a Mendelian neurodegenerative disorder, the genetic risk of Huntington's disease (HD) is
conferred entirely by an HTT CAG repeat expansion whose length is the primary …
conferred entirely by an HTT CAG repeat expansion whose length is the primary …
[PDF][PDF] CAG repeat not polyglutamine length determines timing of Huntington's disease onset
Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted
HTT CAG repeat sequence, distinct from the length of huntingtin's polyglutamine segment …
HTT CAG repeat sequence, distinct from the length of huntingtin's polyglutamine segment …
Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice
S Botolin, MC Faugere, H Malluche, M Orth… - …, 2005 - academic.oup.com
Decreased bone mass, osteoporosis, and increased fracture rates are common skeletal
complications in patients with insulin-dependent diabetes mellitus (IDDM; type I diabetes) …
complications in patients with insulin-dependent diabetes mellitus (IDDM; type I diabetes) …
[HTML][HTML] Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants
OBJECTIVE: Glucosamine (GLN) and chondroitin sulfate (CS) are widely used to alleviate
symptoms of osteoarthritis (OA). However, the mechanism (s) of action of these …
symptoms of osteoarthritis (OA). However, the mechanism (s) of action of these …
Neuropsychiatric symptoms in a European Huntington's disease cohort (REGISTRY)
E van Duijn, D Craufurd, AAM Hubers… - Journal of Neurology …, 2014 - jnnp.bmj.com
Background The majority of Huntington's disease (HD) mutation carriers experience some
psychopathology during their lifetime, varying from irritability to psychosis, but prevalences …
psychopathology during their lifetime, varying from irritability to psychosis, but prevalences …
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …