Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …

Platelets play a crucial role in the maintenance of hemostasis, as well as in thrombosis.
Upon activation, platelets release small membrane-bound microparticles (MPs) containing …

Immunoglobulins, antigens and complement can assemble to form immune complexes (IC).
ICs can be detrimental as they propagate inflammation in autoimmune diseases. Like ICs …

Platelets survey blood vessels, searching for endothelial damage and preventing loss of
vascular integrity. However, there are circumstances where vascular permeability increases …

Platelets are anucleated blood elements highly potent at generating extracellular vesicles
(EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of …

Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1
influenza A virus infection, platelets display activation markers. The platelet activation …

There is a growing appreciation for the contribution of platelets to immunity; however, our
knowledge mostly relies on platelet functions associated with vascular injury and the …

The accumulation of DNA and nuclear components in blood and their recognition by
autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus …

Extracellular vesicles (EV) are small membrane vesicles produced by cells upon activation
and apoptosis. EVs are heterogeneous according to their origin, mode of release …

Microparticles, also called microvesicles, are submicron extracellular vesicles produced by
plasma membrane budding and shedding recognized as key actors in numerous physio …